| 苯妥英锌的药理毒理学初步研究 |
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| 引用本文： | 蒲其松,李毓倩,卢丹,陈湛芳,王鲁石,崔刚,李洪安,陆天才.苯妥英锌的药理毒理学初步研究[J].农垦医学,1990(2). |
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| 作者姓名： | 蒲其松 李毓倩 卢丹 陈湛芳 王鲁石 崔刚 李洪安 陆天才 |
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| 作者单位： | 石河子医学院药学系，石河子医学院药学系，石河子医学院药学系，石河子医学院药学系，石河子医学院药学系，石河子医学院基础部，石河子医学院基础部，石河子医学院基础部 |
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| 摘 要： | 苯妥英锌腹腔注射的ED_(50)和LD_(50)分别为9.74和138.1mg/kg,治疗指数与苯妥英钠接近,刺激性比苯妥英钠小。在亚急性毒性试验中,白细胞总数和血小板数似有减少趋势,血红蛋白含量和血清谷丙转氨酶活力无较大改变。服药结束后,心脏、肝脏、肾脏和全脑病理切片观察,两药毒性差异无显著性。
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| 关 键 词： | 苯妥英锌 苯妥英钠 刺激性 亚急性毒性 |
PRIMARY PHARMACOLOGICAL AND TOXICOLOGICAL STUDY OF PHENYTOIN ZINC |
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| Pu Qisong Li Yaqian Lu Dan Chen Zhanfang Wang Lushi.PRIMARY PHARMACOLOGICAL AND TOXICOLOGICAL STUDY OF PHENYTOIN ZINC[J].Agricultural Reclamation Medicine,1990(2). |
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| Authors: | Pu Qisong Li Yaqian Lu Dan Chen Zhanfang Wang Lushi |
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| Abstract: | ED_(50) and LD_(50) of phenytoin zinc ip were 9.74 and 138.1 mg/kg respectively.The therapeutic index of phenytoin zinc was closed to that of phenytoin sodium, but its irritability was less than that of later. In subacute toxicity tests, no remarkable alternations could be found in hemoglobin and serum glutamicpyruvic transaminase except that the white blood cells and blood platelets were found decreased.At the end of the treatment, toxicity of phenytoin zinc and phenytoin sodium were not revealed any remarkab ledifference by examining pathological sections of the heart, liver, kidney and brain. |
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| Keywords: | Phenytoin zinc phenytoin sodium irritability subacute toxicity |
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