| 胃癌中骨桥蛋白与OCT2的表达及意义 |
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| 引用本文： | 张巧英,姚根有,傅燕萍,赵仲生,张布衣,付琼. 胃癌中骨桥蛋白与OCT2的表达及意义[J]. 临床与实验病理学杂志, 2006, 22(5): 563-567 |
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| 作者姓名： | 张巧英 姚根有 傅燕萍 赵仲生 张布衣 付琼 |
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| 作者单位： | 绍兴文理学院医学院病理学教研室,绍兴,312000;浙江大学病理学与法医学研究所,杭州,310031;浙江省绍兴市人民医院病理科,绍兴,312000;浙江省人民医院病理科,杭州,310014 |
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| 基金项目： | 浙江省科技厅基金资助（No2006C33060） |
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| 摘 要： | 目的探讨骨桥蛋白（osteopontin，OPN）及转录因子OCT2在胃癌中的表达及其与临床病理参数及预后的关系。方法应用组织微阵列技术和免疫组化SP法检测99例胃癌组织中OPN蛋白与OCT2蛋白的表达情况。结果99例胃癌中OPN蛋白及OCT2蛋白的阳性表达率分别为60．61％、54．55％；OPN蛋白表达与肿瘤大小、浸润深度、脉管侵犯、淋巴结转移及远处转移呈正相关；OCT2蛋白表达也与肿瘤大小、浸润深度、脉管侵犯、淋巴结转移及远处转移呈正相关；OPN蛋白表达与OCT2蛋白表达呈正相关；OPN及OCT2蛋白阳性表达病例的平均生存时间和5年生存率均明显低于阴性表达的病例。结论OPN及OCT2蛋白表达可预测胃癌浸润和转移，是指导临床治疗及评估预后的有价指标。
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| 关 键 词： | 胃肿瘤 组织阵列分析 骨桥蛋白 OCT2 免疫组织化学 |
| 文章编号： | 1001-7399(2006)05-0563-05 |
| 收稿时间： | 2006-04-04 |
| 修稿时间： | 2006-06-12 |
Study on the expression and significance of OPN and OCT2 in human gastric carcinoma |
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| ZHANG Qiao-ying,YAO Gen-you,FU Yan-ping,ZHAO Zhong-sheng,ZHANG Bu-yi,FU Qiong. Study on the expression and significance of OPN and OCT2 in human gastric carcinoma[J]. Chinese Journal of Clinical and Experimental Pathology, 2006, 22(5): 563-567 |
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| Authors: | ZHANG Qiao-ying YAO Gen-you FU Yan-ping ZHAO Zhong-sheng ZHANG Bu-yi FU Qiong |
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| Affiliation: | 1. Department of Pathology, Shaoxing University Medical College, Shaoxing 312000, China ; 2.Insititute of Pathology and Forensic Medicine ,Zhejiang University, Hangzhou 310031, China ; 3.Department of Pathology, Shaoxing City Hospital, Shaoxing 312000, China; 4.Department of Pathology, Zhefiang Provincial Hospital, Hangzhou 310014, China |
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| Abstract: | Purpose To study the expression of osteopontin(OPN) and OCT2 in gastric carcinoma and their correlation with clinicpathologic features and survivial time. Methods Tissue microarray (TMA) technique and immunohistochemistry (IHC) were used to detect the expression of OPN and OCT2 in 99 gastric carcinoma specimens. Results Immunohistochemistry results revealed that: from the 99 cases, the positive rates of OPN and OCT2 protein expression were 60.61 %, 54.55 %, respectively; there were significant relationships of OPN protein expression with tumor diameter, invasion depth, vessel invasion, lymph node and distant metastasis; there were significant relationships of OCT2 protein expression with tumor diameter, invasion depth, vessel invasion, lymph node and distant metastasis; There was a positive relationship of OPN protein with OCT2 protein expression; the mean survival time in cases with OPN and OCT2 protein positive expression was significantly shorter than those without OPN and OCT2 protein expression. Conclusion The expression of OPN and OCT2 protein can predict the invasion and metastasis of gastric carcinoma; they can be used as markers of prognosis of gastric carcinoma in clinical practice. |
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| Keywords: | stomach neoplasms tissue array analysis osteopontin OCT2 immunohistochemistry |
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