Obstructive prosthetic atrioventricular valve thrombosis in a woman with congenitally corrected transposition of the great arteries during estrogen replacement therapy for pituitary dysfunction |
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Authors: | Jun Muneuchi Kenichiro Yamamura Yuichi Shiokawa Atsuhiro Nakashima Tomoki Ushijima Ryuji Tominaga |
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Institution: | (1) Department of Cardiovascular Surgery, Otemae Hospital, 1-5-34, Otemae, Chuo-ku Osaka, 540-0008, Japan;(2) Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita Osaka, 565-0871, Japan |
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Abstract: | A 27-year-old woman was admitted because of breathlessness, orthopnea, and hemoptysis. The present patient was diagnosed with
congenitally corrected transposition of the great arteries (cc-TGA) and underwent systemic atrioventricular valve replacement
for severe insufficiency at 23 years of age. She also had been treated with oral conjugated equine estrogen (Premarin) because
of congenital pituitary dysfunction. Despite appropriate anticoagulation therapy with warfarin, echocardiography and fluoroscopy
showed stuck leaflets of the prosthetic valve due to thrombosis. She underwent emergent surgical valve replacement. This rare
association suggests that oral hormone replacement therapy poses a risk of thrombosis especially in patients with cc-TGA after
prosthetic valve replacement. |
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Keywords: | |
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