Detection of multiple strains of Mycobacterium tuberculosis using MIRU-VNTR in patients with pulmonary tuberculosis in Kampala,Uganda |
| |
| Authors: | Katherine R Dickman Lydia Nabyonga David P Kateete Fred A Katabazi Benon B Asiimwe Harriet K Mayanja Alphonse Okwera Christopher Whalen Moses L Joloba |
| |
| Affiliation: | (1) Department of Pediatrics, Boston Medical Center, Boston University, Boston, USA;(2) Department of Medical Microbiology, Makerere University College of Health Sciences, Kampala, Uganda;(3) Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda;(4) Tuberculosis Unit, Mulago National Referral and Teaching Hospital, Kampala, Uganda;(5) Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, USA |
| |
| Abstract: | Background Many studies using DNA fingerprinting to differentiate Mycobacterium tuberculosis (MTB) strains reveal single strains in cultures, suggesting that most disease is caused by infection with a single strain. However, recent studies using molecular epidemiological tools that amplify multiple targets have demonstrated simultaneous infection with multiple strains of MTB. We aimed to determine the prevalence of MTB multiple strain infections in Kampala, and the impact of these infections on clinical presentation of tuberculosis (TB) and response to treatment. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
