Neuroticism-related personality traits are related to symptom severity in patients with premenstrual dysphoric disorder and to the serotonin transporter gene-linked polymorphism 5-HTTPLPR |
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Authors: | Malin Gingnell Erika Comasco Lars Oreland Mats Fredrikson Inger Sundström-Poromaa |
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Institution: | 1. Department of Women’s and Children’s Health, Uppsala University, 751 85, Uppsala, Sweden 4. Department of Psychology, Uppsala University, Uppsala, Sweden 2. Department of Neuroscience, Unit of Pharmacology, Uppsala University, Uppsala, Sweden 3. Centre for Clinical Research V?ster?s, Uppsala University, V?ster?s, Sweden
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Abstract: | Neuroticism has been linked to a functional polymorphism in the serotonin transporter gene (5-HTTLPR), with short-allele carriers
being overrepresented among high-scorers on neuroticism. Studies evaluating neuroticism-related personality traits in relation
to the 5-HTTLPR polymorphism among patients with premenstrual dysphoric disorder (PMDD) and are lacking. The primary aim of
this study was to evaluate the relationship between PMDD and neuroticism-related personality traits, and secondly, to relate
the personality trait scores of PMDD patients to experienced symptom severity and to the 5-HTTLPR short allele. Thirty PMDD
patients and 55 asymptomatic healthy controls were included in the study. The Swedish Universities Scale of Personality was
used to evaluate personality traits. Genotype analyses were available in 27 PMDD patients and 18 healthy controls. Women with
PMDD displayed higher levels of neuroticism-related personality traits (psychic trait anxiety, somatic trait anxiety, embitterment,
stress susceptibility and mistrust) than healthy controls, and these effects were most prominent in women with more severe
luteal phase symptoms. Furthermore, PMDD patients with at least one copy of the short allele of the 5-HTTLPR polymorphism
scored higher on psychic trait anxiety and lack of assertiveness than PMDD patients who were homozygous for the long allele.
PMDD patients who suffer from more severe luteal phase symptoms also display increased scores of neuroticism-related personality
traits in comparison with healthy controls. Within the group of PMDD patients, differences in certain personality trait scores
are associated with the short allele of the 5-HTTLPR polymorphism. |
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