2型糖尿病患者血小板参数变化检测及与血管病变的关系

目的探讨血小板参数（PLT、MPV、PCT和PDM）在2型糖尿病检测中的意义。方法血小板参数测定用拜耳ADVIA70五分类全自动血液分析仪，FPG测定用东芝全自动生化分析仪。结果糖尿病组的MPV、PDW均明显高于对照组（P〈0．05），而PLT明显低于对照组（P〈0．05），两组PCT比较，差异无统计学意义（P〉0．05）。有血管病变组的MPV、PDW均明显高于无血管病变组（P〈0．05），而PLT明显低于无血管病变组（P〈0．05），两组PCT比较，差异无统计学意义（P〉0．05）。结论血小板参数检测有助于2型糖尿病的检测，并且便于判断2型糖尿病患者是否存在血管性病变，从而对糖尿病血管性病变的监控有一定的临床意义。

The Detection of Platelet Parameters in Type 2 Diabetic Patients and Its Correlation with Vascular Pathologic Changes

OBJECTIVE To explore the significance of platelet parameters（PLT, MPV, PCT and PDM） in type 2 diabetes patients. METHODS The platelet parameters （PLT, MPV, PCT and PDM ） were detected by automatic hematology analyzer with Bayer ADVIA 70 five-classification, the FPG was detected by Toshiba automatic biochemical analyzer. RESULTS Compared with control group, diabetic group had significantly higher levels of MPV, PDW （P〈0.05） ; lower levels of PLT （P〈0.05） ; no significant difference in PCT. Compared with non-vascular group, vascular group had significantly higher levels of MPV, PDW （P〈0.05） ; lower levels of PLT （P〈 0.05） ; no significant difference in PCT. CONCLUSION The detection of platelet parameters is useful for diagnosis, monitoring the clinical course and avoiding the vascular pathological changes.