| Anticancer Effect of Curcumin on Human B Cell non-Hodgkin＇s Lymphoma |
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| 引用本文： | 孙春艳,刘新月,陈燕,刘芳.Anticancer Effect of Curcumin on Human B Cell non-Hodgkin＇s Lymphoma[J].华中科技大学学报(医学英德文版),2005,25(4):404-407. |
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| 作者姓名： | 孙春艳 刘新月 陈燕 刘芳 |
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| 作者单位： | Institute of Hematology，Union Hospital，Tongji Medical college，Huazhong University of Science and Technology，Wuhan 430022，China，Institute of Hematology，Union Hospital，Tongji Medical college，Huazhong University of Science and Technology，Wuhan 430022，China，Institute of Hematology，Union Hospital，Tongji Medical college，Huazhong University of Science and Technology，Wuhan 430022，China，Institute of Hematology，Union Hospital，Tongji Medical college，Huazhong University of Science and Technology，Wuhan 430022，China |
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| 基金项目： | This project was supported by a grant from the NationalNatural Sciences Foundation of China （No. 30271672）. |
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| 摘 要： | Curcumin(diferuloylmethane)isayellowpig mentfromtherhizomesofturmeric(Curcumalon gaL.)andisamajorcomponentofvariousrecipesforcurry.Curcuminhasbeenreportedtohaveanumberofpharmacologicaleffectsincludinganti inflammatory,anti oxidant,antiviral,antibacterialandantitumoreffects,whichisattractingmoreandmoreattentionofinvestigators.Curcuminhasin hibitoryeffectsonmanytumorssuchasfoestom achcancer,esophagealcancer,coloncancer,livercancer,mammarytumor,bladdercancer,skincanceraswellasDMBA inducedleukem…
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| 关 键 词： | 抗癌作用 姜黄色素 B细胞 非霍奇金氏淋巴瘤 药物治疗 |
| 收稿时间： | 2005-04-04 |
Anticancer effect of curcumin on human B cell non-Hodgkin's lymphoma |
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| Sun Chunyan,Liu Xinyue,Chen Yan,Liu Fang.Anticancer effect of curcumin on human B cell non-Hodgkin's lymphoma[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2005,25(4):404-407. |
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| Authors: | Sun Chunyan Liu Xinyue Chen Yan Liu Fang |
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| Institution: | (1) Institute of Hematology, Union Hospital, Tongji Medical college, Huazhong University of Science and Technology, 430022 Wuhan, China |
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| Abstract: | Summary To explore the anticancer effect of curcumin on human B cell non-Hodgkin's lymphoma and compare its effects on human B cell
non-Hodgkin's lymphoma cells and normal peripheral blood mononuclear cells (NPBMNCs). MTT assay was used to study the effect
of curcumin on the growth of Raji cells and NPBMNCs. The effect of curcumin on the apoptosis of Raji cells and NPBMNC were
studied by flow cytometry and TDT-mediated dUTP nick and labeling (TUNEL). The effect of curcumin on the cell cycle of Raji
cells were examined by propidium iodide staining flow cytometry. The results showed that curcumin strongly inhibited proliferation
of Raji cells, 24 h IC50 for Raji cells was 22.8±1.82 μmol/L and curcumin induced Raji cell apoptosis in a time- and dose-dependent manner. Raji cells
treated with curcumin showed G0/G1 or G2/M phase increase and S phase decrease. However, curcumin did not demonstrate apparent proliferation inhibition and apoptosis
induction in NPBMNCs. It was concluded that curcumin is able to inhibit the proliferation of Raji cells by regulating the
cell cycle and inducing the cell apoptosis. Morever, curcumin has low toxicity on NPBMNCs but can selectively induce apoptosis
in Raji cells.
Sun Chunyan, female, born in 1976, M. D., Ph. D., Doctor in Charge
This project was supported by a grant from the National Natural Sciences Foundation of China (No. 30271672). |
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| Keywords: | Raji cell curcumin apoptosis cell cycle selectivity |
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