| 美金刚对大鼠脑缺血再灌注后Caspase-3表达及丙二醛含量的影响 |
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| 引用本文： | 赵彦坡,秦洁,孙石磊.美金刚对大鼠脑缺血再灌注后Caspase-3表达及丙二醛含量的影响[J].郑州大学学报(医学版),2011,46(5):748-751. |
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| 作者姓名： | 赵彦坡 秦洁 孙石磊 |
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| 作者单位： | 郑州大学第一附属医院神经内科 郑州450052 |
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| 摘 要： | 目的:观察非竞争性NMDA受体拮抗剂美金刚对大鼠脑缺血再灌注后迟发性脑损伤的抑制作用.方法:雄性Wistar大鼠135只,随机分为假手术组、模型组及干预组,采用线栓法建立大鼠大脑中动脉闭塞(MCAO)局灶性脑缺血再灌注模型,干预组用美金刚溶液灌胃,HE染色观察神经元形态变化,免疫组织化学染色检测神经元Caspase-3...
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| 关 键 词： | 迟发损伤 美金刚 脑缺血 Caspase-3 丙二醛 大鼠 |
Effects of memantine on expression of Caspase-3 and MDA in rats after ischemia-reperfusion |
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| ZHAO Yanpo,QIN Jie,SUN Shilei.Effects of memantine on expression of Caspase-3 and MDA in rats after ischemia-reperfusion[J].Journal of Zhengzhou University: Med Sci,2011,46(5):748-751. |
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| Authors: | ZHAO Yanpo QIN Jie SUN Shilei |
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| Institution: | ZHAO Yanpo,QIN Jie,SUN Shilei Department of Neurology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 |
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| Abstract: | Aim: To investigate the inhibition of NMDA receptor antagonist memantine on the cerebral ischemic injury of delay in rats.Methods:One hundred and thirty-five male Wistar rats were randomly divided into 3 groups:sham-operation group,model group,and intervention group.The models of cerebral ischemia-reperfusion injury rats were established by the middle cerebral artery occlusion(MCAO).The rats of intervention group were treated with memantine.The changes of cell morphology and the expression of Caspase-3 in c... |
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| Keywords: | injury of delay memantine cerebral ischemia Caspase-3 MDA rat |
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