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| 大鼠卡那霉素耳中毒后耳蜗TMPRSS3蛋白的表达 | |
| 引用本文： | Peng A,Ge S,Wang Q,Xie D,Wu W,Xiao Z. 大鼠卡那霉素耳中毒后耳蜗TMPRSS3蛋白的表达[J]. 中南大学学报(医学版), 2011, 36(10): 987-991. DOI: 10.3969/j.iasn.1672-7347.2011.10.009 |
| 作者姓名： | Peng A Ge S Wang Q Xie D Wu W Xiao Z |
| 作者单位： | 中南大学湘雅二医院耳鼻咽喉头颈外科, 中南大学耳科研究所, 长沙 410011 |
| 基金项目： | 国家自然科学基金(30700940)~~ |
| 摘 要： | 目的:建立氨基甙类抗生素(aminoglycoside antibiotics,AmAn)致聋动物模型,观察内耳跨膜丝氨酸蛋白酶3(transmembrane protease,serine 3,TMPRSS3)的表达变化,探讨其在AmAn致聋中的作用机制.方法:选取健康SD大鼠40只,随机分为4组:对照组、硫酸卡那霉... |
| 关 键 词： | 跨膜丝氨酸蛋白酶3 硫酸卡那霉素 耳蜗 耳毒性 |
Expression of TMPRSS3 in the rat cochlea following kanamycin ototoxicity |
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| Peng Anquan,Ge Shenglei,Wang Qin,Xie Dinghua,Wu Weijing,Xiao Zi'an. Expression of TMPRSS3 in the rat cochlea following kanamycin ototoxicity[J]. Journal of Central South University. Medical sciences, 2011, 36(10): 987-991. DOI: 10.3969/j.iasn.1672-7347.2011.10.009 | |
| Authors: | Peng Anquan Ge Shenglei Wang Qin Xie Dinghua Wu Weijing Xiao Zi'an |
| Affiliation: | Department of Otolaryngology-Head & Neck Surgery, Second Xiangya Hospital; Institute of Otology, Central South University, Changsha 410011, China |
| Abstract: | Objective To establish the kanamycin-induced deafness model in SD rats,and to investigate the expression and significance of transmembrane protease,serine 3(TMPRSS3) in the cochlea following kanamycin ototoxicity.Methods A total of 40 male SD rats were randomly divided into 4 groups.The experimental rats received intramuscular kanamycin sulfate for 3,7,and 14 consecutive days,and the control group were treated with normal saline for 14 days.Auditory brainstem responses(ABR) were obtained before and after th... |
| Keywords: | transmembrane protease serine 3 kanamycin cochlea ototoxicity |
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