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| CD4+CD25+FoxP3+免疫调节细胞在不同免疫应答状态乙型肝炎疫苗接种者中的表达 | |
| 作者姓名： | Li J Tan D Liu H Li K |
| 作者单位： | 1. 中南大学湘雅医院感染科, 长沙 410008; 2. 邵阳医学高等专科学校内科学教研室, 湖南 邵阳 422000; 3. 珠海市妇幼保健院检验中心, 珠海 519001 |
| 基金项目： | supported by the funds from the Department of Science & Technology(2007FJ3092); the Department of Education(07C065); the Department of Public Health(B2007194),Hunan province,P.R.China |
| 摘 要： | 目的:通过对乙型肝炎病毒疫苗接种后不同免疫应答人群CD4+ CD25+T调节细胞(T regulatory cells,Tregs)及FoxP3 mRNA的表达及细胞因子分泌的检测,探讨乙型肝炎病毒疫苗接种后免疫应答与免疫调节细胞和细胞因子之间的内在联系.方法:采集不同反应人群(应答组18例,无应答组22例,对照组10... |
| 关 键 词： | 乙型肝炎疫苗 T调节细胞 抗原 CD4 CD25 FoxP3 疫苗应答 |
CD4(+) CD25(+) FoxP3(+) T regulatory cells in subjects responsive or unresponsive to hepatitis B vaccination |
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| Li J,Tan D,Liu H,Li K.CD4(+) CD25(+) FoxP3(+) T regulatory cells in subjects responsive or unresponsive to hepatitis B vaccination[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),2011,36(11):1046-1051. | |
| Authors: | Li Jincheng Tan Deming Liu Hongbo Li Kecheng |
| Institution: | 1. Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008; 2. Department of Internal Medicine, Shaoyang Medical College, Shaoyang Hunan 422000; 3. Laboratory Center, Maternal and Child Care Hospital of Zhuhai, Zhuhai 519001, China |
| Abstract: | Objective To determine CD4+CD25+ T regulatory cells(Tregs),forkhead box P3(FoxP3) mRNA expression and levels of cytokines secreted by peripheral blood mononuclear cells(PBMCs) in individuals responsive or unresponsive to hepatitis B(HB) vaccination,and to explore the relationships between immune response and immune regulatory cells or cytokines.Methods Based on the antibody against hepatitis B surface antigen(HBsAg) after HB vaccination,the CD4+CD25+ Tregs frequencies in PBMCs from 18 responders,22 nonrespo... |
| Keywords: | hepatitis B vaccines T regulation cells antigen CD4 CD25 FoxP3 immune response |
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