| 复方连芩双层缓释药膜的制备及质量控制 |
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| 引用本文： | 汪风芹,孙迎东,邢树礼,成文娜,宋征. 复方连芩双层缓释药膜的制备及质量控制[J]. 齐鲁药事, 2012, 31(9): 531-532 |
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| 作者姓名： | 汪风芹 孙迎东 邢树礼 成文娜 宋征 |
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| 作者单位： | 滨州医学院附属医院,山东,滨州,256603 |
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| 基金项目： | 滨州市科技局2011年度资助项目 |
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| 摘 要： | 目的建立复方连芩双层缓释药膜的制备方法及其质量控制方法。方法以高分子缓释材料PVA17-18及CMC-Na为成膜载体,采用薄层色谱法对处方中的黄连、黄柏、黄芩苷等进行定性鉴别,采用紫外分光光度法测定其中阿昔洛韦的含量。结果阿昔洛韦在2.0～15.0μg.mL-1范围内线性关系良好,平均回收率为98.36%(RSD=1.08%)。结论该膜剂制备方法简单,质量可靠。
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| 关 键 词： | 膜剂 制备 手足口病 紫外分光光度法 |
Preparation and quality control of compound Lianqin Double Sustained-release Membrane |
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| WANG Feng-qin , SUN Ying-dong , XING Shu-li , CHENG Wen-na , SONG Zheng. Preparation and quality control of compound Lianqin Double Sustained-release Membrane[J]. qilu pharmaceutical affairs, 2012, 31(9): 531-532 |
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| Authors: | WANG Feng-qin SUN Ying-dong XING Shu-li CHENG Wen-na SONG Zheng |
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| Affiliation: | ( The Affiliated Hospital of Binzhou Medical College, Binzhou 256603, China ) |
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| Abstract: | Objective To establish a preparation and quality control method for compound Lianqin Double Sustained - re- lease Membrane. Methods PVA17 - 18 and CMC - Na were used as membrane carrier. The coptis chinensis franeh,amur eorktree bark and bicalin were qualitatively identified by TLC. The content of aeielovir was determined by UV - spectrophotometry. Results The linear range of aciclovir was 2.0 - 15.0 μg .mL^-1 and the average recovery was 98.36% （ RSD = 1.08% ）. Conclusion This method was simple, and the quality of membrane was reliable. |
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| Keywords: | Membrane Preparation Hand foot and mouth disease UV - Spectrophotometry |
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