| 60例炎症性肌病患者的预后及影响因素的分析 |
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| 引用本文： | 李悦,陈博,林婧,罗璇,桂梦翠,卜碧涛. 60例炎症性肌病患者的预后及影响因素的分析[J]. 神经损伤与功能重建, 2012, 7(3) |
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| 作者姓名： | 李悦 陈博 林婧 罗璇 桂梦翠 卜碧涛 |
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| 作者单位： | 李悦 (华中科技大学同济医学院附属同济医院神经内科,武汉,430030) ； 陈博 (华中科技大学同济医学院附属同济医院神经内科,武汉,430030) ； 林婧 (华中科技大学同济医学院附属同济医院神经内科,武汉,430030) ； 罗璇 (华中科技大学同济医学院附属同济医院神经内科,武汉,430030) ； 桂梦翠 (华中科技大学同济医学院附属同济医院神经内科,武汉,430030) ； 卜碧涛 (华中科技大学同济医学院附属同济医院神经内科,武汉,430030) ； |
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| 摘 要： | 目的:总结特发性炎症性肌病(IIM)的临床特征并分析影响IIM预后的因素。方法:分析60例IIM患者的临床资料,对临床症状、肌酶水平、生活质量等进行跟踪随访。结果:60例患者男女性别比约为1∶2;100%表现出不同程度的四肢无力,38.3%(23/60)存在吞咽困难等球麻痹症状,31.7%(19/60)出现胸闷;随访期内临床缓解率为68.0%,缓解后复发率18.0%,死亡率为10.0%;多元Logistic回归分析显示,胸闷(OR=13.20)、吞咽困难(OR=3.36)、四肢肌力(OR=2.12～3.78)、ADL评分高(OR值=1.06)是IIM预后不良的危险因素。结论:随访期间,IIM患者在临床症状及血清学指标上逐步好转;心脏疾病、肺部疾病、肿瘤等合并症发生率相对较高;伴随胸闷、吞咽困难、起病症状较重的患者预后不良。
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| 关 键 词： | 炎症性肌病 临床转归 预后因素 |
Analysis of Prognosis and Influencing Factors of 60 Patients with Idiopathic Inflammatory Myopathies |
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| Abstract: | Objective: To assess the long-time outcomes of idiopathic inflammatory myopathies patients and to evaluate the prognostic factors.Methods: The clinical data of 60 patients with idiopathic inflammatory myopathies were documented and followed up.Results: In this study,39 patients were female and 21 were male.The patients showed the symptoms of muscle weakness(60/60),dysphagia(23/60),and chest tightness(19/60).The clinic improvement rate was 68%,the relapse rate was 18%,and mortality rate was10%.The Logistic regression analysis showed that chest tightness(OR=13.20),dysphagia(OR value=3.36),limb muscle strength(OR=2.12~3.78),and the ADL score(OR value=1.06) were significantly related to prognosis.Conclusion: The majority of patients undergo good prognosis.Complications occur most commonly in patients with cancer,heart disease or lung disease.More attention should be paid to acute onset of severe symptoms,the complications such as chest tightness and dysphagia,which are associated with poor outcomes. |
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| Keywords: | idiopathic inflammatory myopathies outcomes prognostic factors |
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