湘潭市中心医院社区获得性肺炎住院患儿肺炎链球菌的耐药性研究

目的了解湘潭市中心医院因社区获得性肺炎住院的患儿肺炎链球菌(SP)的耐药情况。方法对本院2010-2011年住院患儿分离的115株SP进行分析,采用K-B纸片琼脂扩散法及浓度梯度法(E测试)检测SP对青霉素、头孢曲松、红霉素、克林霉素、左氧氟沙星、万古霉素、利奈唑胺、复方磺胺甲噁唑的耐药性。结果 115株SP中青霉素敏感肺炎链球菌(PSSP)占86.1%,青霉素中介肺炎链球菌(PISP)占7.8%,青霉素耐药肺炎链球菌(PRSP)占6.1%。SP对红霉素、克林霉素及复方磺胺甲噁唑的耐药率分别为95.6%、94.8%和73.9%,左氧氟沙星的耐药率为1.7%,头孢曲松的耐药率为6.9%,未发现对万古霉素及利奈唑胺耐药的SP菌株。结论本院分离的SP对儿科常用抗生素青霉素及头孢曲松钠仍高度敏感,但对大环内酯类抗生素红霉素、林可酰胺类抗生素克林霉素耐药情况严重。

Drug resistance analysis of Streptococcus pneumoniae isolated from paediatric patients hospitalized for community-acquired pneumonia in Xiangtan central hospital

Objective To investigate the drug resistance of Streptococus pneumoniae(SP)isolated from paediatric patients hospitalized for community-acquired pneumonia in Xiangtan central hospital.Methods A total of 115 SP strains isolated from children in hospital from 2010 to 2011 were analyzed.Bacterial susceptibility test was carried out by using Kirby-Bauer and E-test metods.Results The resistance rates of SP against penicillin,erythromycin,clindamycin,levofloxacin,ceftriaxone,vancomycin,linezolid and sulfamethoxazole-trimethoprim were 6.1%,95.6%,94.8%,1.7%,6.9%,0%,0% and 73.9% respectively.Conclusion The susceptible rate of SP to erythromycin and clindamycin is extremely low,but it is very high to penicillin and ceftriaxone.