整合子-基因盒体系与细菌耐药关系及研究进展

目前,细菌耐药性已经对公共卫生问题构成严重威胁,整合子-基因盒体系是介导细菌获得耐药性与耐药基因播散的重要分子机制。整合子在整合酶作用下识别并俘获游离耐药基因盒,随着转座子或接合性质粒播散,造成细菌间耐药基因的扩散和多重耐药性的产生。本文就整合子-基因盒体系的结构、分类、分布、起源及播散机制等几方面研究近况开展讨论。

Advances in the relationship between integron-gene cassette system and drug-resistance of bacteria

The bacteria resistance has posed a serious threat to the public health problem at present.Integron-gene cassette system played an important role in bacteria capturing and disseminating antibiotic resistance gene.Integron identified and captured free resistance gene box under the action of integrase.The spread of transposons and zygosity plasmid caused diffusion of drug-resistant genes and multiple resistance effects in different bacteria.This article reviewed the construction,class,distribution,source of integron and gene cassettes and spread mechanism of integron-gene cassette system.