|
|||||
|
|
| E选择素、P选择素在人脑胶质瘤中的表达意义 | |
| 引用本文： | 傅军,张一,周幽心,张成生,范映忠. E选择素、P选择素在人脑胶质瘤中的表达意义[J]. 四川医学, 2009, 30(11): 1696-1698 |
| 作者姓名： | 傅军 张一 周幽心 张成生 范映忠 |
| 作者单位： | 1. 内江市第一人民医院神经外科,四川,内江,641000 2. 苏州大学附属第三人民医院神经外科,江苏,常州,213003 3. 苏州大学附属第一人民医院神经外科,江苏,苏州,215006 |
| 摘 要： | 目的通过检测E选择素、P选择素在人脑胶瘤中的表达,探讨其与胶质瘤浸润发展的关系。方法采用免疫组织化学SP法分别检测E选择素、P选择素在61例人脑胶质瘤和8例正常人脑组织中的表达。结果①E选择素、P选择素在胶质瘤组中的阳性表达率分别为60.7%、57.4%;较对照组明显增高（P〈0.05）。②E选择素在胶质瘤Ⅰ～Ⅱ级组和Ⅲ～Ⅳ级组中的阳性表达率分别为46.9%、75.9%,随肿瘤级别增高表达水平也明显增高（P〈0.05）。P选择素在不同级别胶质瘤中的表达率差异无统计学意义（P〉0.05）。③E选择素、P选择素在人脑胶质瘤中的表达无显著相关（R=0.14498,P=0.2649）。结论E选择素、P选择素可能与人脑胶质瘤的浸润发展有关。 |
| 关 键 词： | E选择素 P选择素 胶质瘤 |
The expression and signifcance of E-selectin P-selectin in human gliomas |
|
| Affiliation: | FU Jun ,ZHANG Yi ,ZHOU You-xin ,et al. (1. The First People＇s Hospital of Neijiang , Neijiang , Sichuan 641000;2. The Third Affiliated Hospital of Suzhou University,Changzhou,Jiangsu 213003 ;3. The First Affiliated Hospital of Suzhou University,Suzhou ,Jiangsu 215006, China) |
| Abstract: | Objective To investigate the expression of E-selectin, P-selectin in gliomas and the relation between the selectins. Methods The expression of E-selectin, P-selectin are detected in paraffin sections by using SP immunohistochemical method. Results ①The positive expression rate of E-seleetin and P-selectin in gliomas are significantly higer than in control group（P〉0. 05） ;②The expression rate of E-selectin in gliomas of grade Ⅰ-Ⅱ are significantly lower than in gliomas of grade Ⅲ-Ⅳ （ P〈0. 05 ）. There are no differences of expression of P-selectin between grade Ⅰ-Ⅱ and grade Ⅲ-Ⅳ of glioma group （P〉0. 05） ;③There is no relation between the expression of the two selectins in gilomas. Conclusion E-selectin,P-selectin may be correlated to the oncogenisis and progression of gliomas. |
| Keywords: | E-selectin P-selectin glioma |
| 本文献已被 维普 万方数据 等数据库收录！ | |