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Strain differences in the effects of adrenalectomy on the midbrain dopamine system: implication for behavioral sensitization to cocaine |
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| Authors: | de Jong I E M Steenbergen P J de Kloet E R |
| Affiliation: | aLeiden/Amsterdam Center for Drug Research and Leiden University Medical Center, Division of Medical Pharmacology, Gorlaeus Laboratories, Einsteinweg 55, P.O. Box 9502, 2300 RA Leiden, The Netherlands bH. Lundbeck A/S, Department of Psychopharmacology Ottiliavej 9, 2500 Valby, Denmark |
| Abstract: | Adrenalectomy (ADX) abolishes behavioral sensitization to cocaine in DBA/2, but not C57BL/6 inbred mice. The present study tests the hypothesis that this ADX effect on behavioral sensitization in the DBA/2 strain involves changes in midbrain dopamine systems that do not occur in the C57BL/6 strain. |
| Keywords: | glucocorticoids HPA-axis genotype locomotion C57BL/6 DBA/2 |
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