白细胞介素-10启动子基因多态性与缺血性卒中相关性的Meta分析

目的 系统评价IL-10启动子基因（IL-10-1082A/G、IL-10-819T/C ）多态性与缺血性卒中（i s chemi c
stroke，IS）发病风险的相关性。
方法 计算机检索Pubmed、Embase、Web of Science、万方数据库及中国知网数据库发表的有关IL-10启
动子基因多态性与IS发病风险相关性的研究，检索时限为从建库至2019年2月，由2名评价者按照纳入
与排除标准选择研究、提取资料。采用RevMan 5.3软件进行荟萃分析。
结果 共纳入13篇病例对照研究，其中12篇文献研究了IL-10-1082A/G 基因多态性与I S的易感性，6
篇文献研究了IL-10-819T/C 基因多态性与I S的易感性。结果显示，在总体人群中，IL-10-1082A/G基因多
态性与I S发病风险之间存在相关性（G vs A：OR 0.71，95%CI 0.59～0.86，P＜0.001；GG vs AA：OR 0.61，
95%CI 0.49～0.76，P＜0.001；AG vs AA：OR 0.72，95%CI 0.55～0.94，P =0.020；GG+AG vs AA：OR 0.68，
95%CI 0.53～0.87，P =0.002；GG vs AG+AA：OR 0.68，95%CI 0.52～0.89，P =0.005）；而IL-10-819T/C
基因多态性与IS发病风险无明显相关性（P＞0.05）。对中国人群进行亚组分析后，Meta分析结果与总
体人群一致。
结论 IL-10-1082A/G基因的多态性与IS风险显著相关，该基因是卒中易感基因；而IL-10-819T/C基因
多态性与IS的发病风险无明显关联。

Association of Interleukin-10 Promoter Gene Polymorphism with Ischemic Stroke: a Meta Analysis

Objective To systematically review the association between IL-10 promoter gene (IL-10-1082A/G ,
IL-10-819T/C ) polymorphism and the risk of ischemic stroke (IS) by meta analysis.
Methods Databases of PubMed, Embase, Web of Science, WanFang Data and CNKI were
electronically searched for the literature published up to February 2019 on the association
between IL-10 promoter gene polymorphism and IS risk. According to the inclusion and exclusion
criteria,the studies were screened and the data were extracted by 2 reviewers. The data were
analyzed using the RevMan 5.3 software.
Results A total of 13 case-control studies were included, including 12 articles on the correlation
between IL-10-1082A/G gene polymorphism and IS, and 6 articles on the correlation between IL-
10-819T/C gene polymorphism and IS. The meta analysis results showed a significant association
between IL-10-1082A/G gene polymorphism and IS risk in the total included patients, (G vs A: OR
0.71, 95%CI 0.59-0.86, P <0.001; GG vs AA: OR 0.61, 95%CI 0.49-0.76, P <0.001; AG vs AA: OR
0.72, 95%CI 0.55-0.94, P =0.020; GG+AG vs AA: OR 0.68, 95%CI 0.53-0.87, P =0.002; GG vs
AG+AA: OR 0.68, 95%CI 0.52-0.89, P =0.005); while there was no obvious correlation between
IL-10-819T/C gene polymorphism and IS risk (P >0.05). The results of subgroup analysis in theChinese population were consistent with the overall analysis results.
Conclusions IL-10-1082G/A gene polymorphism was associated with IS risk, which is stroke
susceptibility gene; IL-10-819T/C gene polymorphism was not associated with IS risk.