Non-disjunction in human sperm: evidence for an effect of increasing paternal age |
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| Authors: | Griffin, Darren K. Abruzzo, Michael A. Millie, Elise A. Sheean, Leon A. Feingold, Eleanor Sherman, Stephanie L. Hassold, Terry J. |
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| Affiliation: | Department of Genetics and the Center for Human Genetics and University Hospitals of Cleveland Cleveland, OH 44106 1Department of Reproductive Biology, Case Western Reserve University and University Hospitals of Cleveland Cleveland, OH 44106 2Department of Biostatistics, Emory University School of Public Health, Emory University School of Medicine Atlanta, GA 30322, USA 3Department of Genetics and Molecular Medicine, Emory University School of Medicine Atlanta, GA 30322, USA |
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| Abstract: | In humans, the relationship between advancing maternal age andthe incidence of trisomy has been long established, but thepossible effect of increasing age of the father remains controversial.Using a fluorescence in situ hybridization (FISH) approach todirectly examine individual sperm for aneuploidy of the sexchromosomes and chromosome 18, we have analyzed |
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