Linkage of Chido and HL-A |
| |
| Authors: | JANICE Middleton MARIE C Crookston JUDITH A Falk ELIZABETH B Robson P J L Cook J R Batchelor JULIA Bodmer G B Ferrara H Festenstein R Harris F Kissmeyer-nielsen SYLVIA D Lawler J A Sachs EVA Wolf |
| |
| Institution: | Department of Hematology, Toronto General Hospital, Toronto, Canada;Tissue Typing Laboratory, Toronto Western Hospital, Toronto, Canada;MRC Human Biochemical Genetics Unit, The Galton Laboratory, University College, London, England;McIndoe Memorial Research Unit, Queen Victoria Hospital, East Grinstead, Sussex, England;Genetics Laboratory, Department of Biochemistry, Oxford, England;Immunology Research Center, Ospedale Generale Provinciale, Massa, and AVIS, Bergamo, Italy;Transplantation Immunology Unit, The London Hospital Medical College, London, England;Department of Medical Genetics, St. Mary's Hospital, Manchester, England;Blood Grouping Laboratory, Municipal Hospital, Aarhus, Denmark;Department of Clinical Research, Royal Marsden Hospital, London, England |
| |
| Abstract: | Of 156 families who were HL-A typed and Chido-typed, 15 were found to be suitable for linkage analysis. It was calculated that the odds in favour of linkage of Chido and HL-A are 1,450,000:1. The maximum likelihood estimate of the Chido : 1.HL-A recombination fraction is 2½% with 95% confidence limits, obtained graphically, of 0 and 12%; the estimate of the Chido : 2.HL-A recombination fraction is 1½%, with limits of 0 and 9%. Among Chido negative subjects, the antigens HL-A12 and W5 occurred more frequently than in a control population. |
| |
| Keywords: | |
|
|
