食管癌和肺癌术后并发房颤的分析及比较

目的分析食管癌和肺癌术后并发房颤的发生率、高危因素、治疗方法及预后，并加以比较。方法将2004年12月～2006年5月45例食管癌和肺癌术后并发房颤的患者分为食管癌组（27例）和肺癌组（18例），并加以总结。结果食管癌组手术时间及术后2d尿中儿茶酚胺的含量高于肺癌组（P〈0．001）。肺癌组术后并发低氧血症的发生率高于食管癌组（P〈0．05）。术前合并心脏病病史及慢性阻塞性肺疾病病史，两组比较差异无统计学意义（P〉0．05）。45例患者均治愈。结论食管癌较肺癌术后易并发房颤。术后并发房颤的食管癌患者应及早进行药物治疗，肺癌患者首先应去除病因治疗。

Comparative analysis of postoperative atrial fibrillation in esophagus cancer and lung cancer patients

Objective To investigate the effects of apoptosis and related gene p21WAF1 and Bcl-2 in the tumorigenesis of primary gallbladder neoplasms. Methods p21WAF1 and Bcl-2 were detected by immunohistochemistry and apoptotic cells were stained in situ by terminal deoxynucleotidyl transferase mediated-dUTP nick end labeling(TUNAL) in 46 cases of primary gallbladder neoplasms with different histological grades. Results Apoptotic index and p21WAF1 were decreased,but the expression of Bcl-2 was increased with the increasing of the histological grades in primary gallbladder neoplasms (P<0.05). p21WAF1 expression was positively and Bcl-2 expression was negatively associated with the rate of apoptosis(r=0.52,P<0.05; r=-0.58,P<0.05 respectively). Conclusion It indicates that apoptosis has an important role in the tumorigenesis of primary gallbladder neoplasms, p21WAF1 and Bcl-2 take part in the occurrence and progression of primary gallbladder neoplasms.