| 清营汤对实验性糖尿病大鼠肾脏早期病变的影响 |
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| 引用本文： | 付丽媛,翟玉祥,杨进,王灿辉,卞慧敏.清营汤对实验性糖尿病大鼠肾脏早期病变的影响[J].中药药理与临床,2007,23(2):2-4. |
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| 作者姓名： | 付丽媛 翟玉祥 杨进 王灿辉 卞慧敏 |
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| 作者单位： | 南京中医药大学温病教研室,南京,210029 |
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| 摘 要： | 目的:探讨清营汤对实验性糖尿病大鼠早期肾脏病变的防治作用。方法:腹腔注射链脲佐菌素(STZ)造成实验性糖尿病大鼠,成模后8周,观察各组间肾重/体重、血与肾组织中MDA、肾超微结构的变化。结果:病理组大鼠肾重/体重、肾组织与血中的MDA明显升高,而清营汤组的肾重/体重、肾组织与血中的MDA明显降低,清营汤组基底膜的增厚与系膜的增生不明显。结论:清营汤对糖尿病大鼠早期肾脏病变的干预作用可能是通过抑制大鼠体内脂质过氧化而达到的。
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| 关 键 词： | 清营汤 链脲佐菌素 糖尿病肾病 |
| 文章编号： | 24390349 |
Effect of Qinyin Decoction(清营汤) on early nephropathy of the experimental diabetic rats |
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| Fu Liyuan,Zhai Yuxiang,Yang Jin,Wang Canhui,Bian Huimin.Effect of Qinyin Decoction(清营汤) on early nephropathy of the experimental diabetic rats[J].Pharmacology and Clinics of Chinese Materia Medica,2007,23(2):2-4. |
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| Authors: | Fu Liyuan Zhai Yuxiang Yang Jin Wang Canhui Bian Huimin |
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| Institution: | SFD Department, Nanjing University of TCM, Nanjing 210029 |
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| Abstract: | Objective: To investigate the effect of Qinyin Decoction on early nephropathy of the experimental diabetic rats. Methods: SD rats model were established by intraperitoneal injection of streptozotocin(STZ).Model rats were randomly divided into model group, control group(treated by gliclazide),and experimental groups (treated by Qinyin Decoction). Weigh and kidney weigh were observed. The morphological change of glomerule were checked through electronic microscopy. Blood glucose and MDA of blood and kidney were analyzed with chemical methods. Results: Qinyin Decoction markedly reduced the level of the rate of kidney index, malondialdehyde(MDA) in blood and kidney of diabetic rats, which increased significantly in the model group. Conclusion: The results suggest that Qinyin Decoction may be used to therapy diabetic early nephropathy by inhibition lipid oxidation. |
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