Interaction between digoxin and tricyclic antidepressants in the rat |
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| Authors: | T Attree P Sawyer M J Turnbull |
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| Affiliation: | 1. Department of Pharmacy, UC San Diego Health, San Diego, California;2. UC San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, California;3. Department of Emergency Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas;4. Department of Emergency Medicine, Behavioral Emergencies Research Laboratory, Little Rock, Arkansas;1. Department of Internal Medicine, Division of Gastroenterology and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan;3. Department of Internal Medicine, Division of Gastroenterology, Baylor College of Medicine, Houston, Texas;4. Departments of Medicine, Harvard Medical School, Tufts University School of Medicine, Newton-Wellesley Hospital, and Massachusetts General Hospital, Boston, Massachusetts;6. Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;1. Department of Optics and Laser Engineering, Estahban Branch, Islamic Azad University, Estahban, Iran;2. Department of Physics, College of Sciences, Yasouj University, Yasouj, 75914-353, Iran;1. Kilis 7 Aralık University, Vocational High School of Health Services, Department of Opticianry, 79000 Kilis, Turkey;2. Firat University, Sciences Faculty, Department of Chemistry, 23119 Elazig, Turkey;3. Ondokuz Mayıs University, Arts and Sciences Faculty, Department of Physics, 55139 Samsun, Turkey;1. Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, IN 47907, USA;2. Department of Chemistry and Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA;3. Purdue Institute for Drug Discovery and Institute for Inflammation, Immunology, and Infectious Diseases, West Lafayette, IN 47907, USA;1. Laboratoire de pharmacologie, pharmacogénétique et toxicologie, CHU de Grenoble-Alpes, CS 10217, 38043 Grenoble cedex 9, France;2. Clinique de médecine légale, CHU de Grenoble Alpes, France;3. Laboratoire de pharmacologie, CHU de Nîmes, France;4. Laboratoire de biochimie-toxicologie, centre hospitalier Lyon-Sud, hospices civils de Lyon, Pierre-Bénite, France |
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| Abstract: | A possible interaction between digoxin and tricyclic antidepressants has been investigated in the rat. Acute administration of desmethylimipramine, 20 or 40 mg/kg, i.p., but not of imipramine, amitriptyline or nortriptyline, increased the lethality of i.v. infused digoxin in urethane anaesthetised rats. Chronic administration, 10 mg/kg/day for 14 days in the drinking water, of imipramine or desmethylimipramine, but not of amitriptyline or nortriptyline, also significantly increased digoxin toxicity. Mild stress did not significantly affect the toxicity of digoxin but stressing animals in the presence of amitriptyline or imipramine significantly increased the lethality of digoxin. Reserpine pretreatment afforded significant protection against digoxin. The role of catecholamines in this interaction is discussed. |
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