| 吩噻嗪类化合物的合成及其光化学病毒灭活活性研究 |
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| 引用本文： | 文辉,王小芳,黄毅,王憬惺,杨光中.吩噻嗪类化合物的合成及其光化学病毒灭活活性研究[J].药学学报,2010,45(1):72-76. |
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| 作者姓名： | 文辉 王小芳 黄毅 王憬惺 杨光中 |
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| 作者单位： | (1. 中国医学科学院、北京协和医学院药物研究所, 北京 100050; 2. 中国医学科学院、北京协和医学院输血研究所, 四川 成都 610081) |
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| 摘 要： | 光化学病毒灭活法目前被用于血液产品病毒灭活处理, 其中亚甲蓝 (MB) 光化学法能够有效地进行血细胞制品病毒灭活。以MB为先导物, 设计合成了12个新结构的吩噻嗪类化合物, 并进行了初步病毒灭活、红细胞损伤等实验, 结果显示测试样品中化合物YWW-7在活性和可能的副作用等方面的表现均优于MB, 有希望开发成为全新的血液产品病毒灭活剂。
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| 关 键 词： | 吩噻嗪 病毒灭活 合成 |
Synthesis and photochemical virus inactivation of novel phenothiazines |
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| WEN Hui,WANG Xiao-fang,HUANG Yi,WANG Jing-xing,YANG Guang-zhong.Synthesis and photochemical virus inactivation of novel phenothiazines[J].Acta Pharmaceutica Sinica,2010,45(1):72-76. |
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| Authors: | WEN Hui WANG Xiao-fang HUANG Yi WANG Jing-xing YANG Guang-zhong |
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| Institution: | WEN Hui1,WANG Xiao-fang1,HUANG Yi2,WANG Jing-xing2,YANG Guang-zhong1 (1. Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050,China,2. Institute of Blood Transfusion,Chengdu 610081,China) |
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| Abstract: | Virus inactivation with photochemistry is being suitable for blood or blood products, methylene blue (MB)/light treatment has been used for viral inactivation of cellular blood components. Twelve new phenothiazines derivatives were designed and synthesized, and were used to test viral inactivation and red cell damage preliminary. Results showed that compound YWW-7 has a satisfactory activity, it could be developed as a new viral inactivation agent for blood products. |
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| Keywords: | phenothiazine virus inactivation synthesis |
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