| N端脑钠肽前体与心力衰竭患者心功能及预后关系的研究 |
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| 引用本文： | 张婷,廖伟娇,高俊,陈涛.N端脑钠肽前体与心力衰竭患者心功能及预后关系的研究[J].中国热带医学,2011,11(6):767-768. |
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| 作者姓名： | 张婷 廖伟娇 高俊 陈涛 |
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| 作者单位： | 广州医学院第一附属医院检验件,广东,广州,510000 |
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| 摘 要： | 目的探讨N端脑钠肽前体（NT-proBNP）与心力衰竭患者心功能NYHA分级及左室射血分数（LVEF）的关系，研究NT—proBNP对心力衰竭患者的诊断及预后的临床价值。方法选取106例心力衰竭患者，心功能情况按照纽约心脏病协会（NYHA）分级，采用电化学发光法测定NT-proBNP的含量，心脏彩色多普勒超声测定左室结构和左室射血分数。研究NT-pmBNP的变化与心功能NYHA分级厦左室射血分数和预后的关系。结果NT-pmBNP水平与LVEF值之间呈负相关（r=-0．736，P〈0．05），随着NYHA心功能分级的增加，患者的NT—pmBNP含量升高，各组间比较具有显著性差异（P〈0．05），动态监测NT—pmBNP发现，治疗“有效”组的心衰患者NT—proBNP水平与治疗前比降低，而心衰“死亡”组患者在治疗后的NT-proBNP水平较治疗前基线下降少，甚至升高。结论NT—pmBNP能够反映心功能的状态，它对心力衰竭患者的诊断、治疗监测及预后的评估具有重要意义。
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| 关 键 词： | N端脑钠肽前体 心力衰竭 心功能 -N后 |
Correlation of N-Terminal-pro-B-type natriuretic peptide with heart function and prognosis of heart failure patients |
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| ZHANG Ting,LIAO Wei-jiao,GAO Jun,et al.Correlation of N-Terminal-pro-B-type natriuretic peptide with heart function and prognosis of heart failure patients[J].China Tropical Medicine,2011,11(6):767-768. |
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| Authors: | ZHANG Ting LIAO Wei-jiao GAO Jun |
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| Affiliation: | ZHANG Ting,LIAO Wei-jiao,GAO Jun,et al(.Department of Clinical Laboratory,the First Affiliated Hospital ofGuangzhou Medical College,Guangzhou 510120,Guangdong,P.R.China) |
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| Abstract: | Aim To investigate correlation between N-Terminal-pro-B-type natriuretic peptide (NT-proBNP) and the the heart function of heart failure patients.Methods The levels of serum or plasma NT-proBNP in 106 heart failure patients classified by NYHA were measured by electrochemiluminescent immunoassay,the left ventricular structure and LVEF were examined by echocardio-graphy,last correlation was analysed with nonparametric test.Results The level of NT-proBNP showed negative correlation with the value of LVEF(r=-0.... |
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| Keywords: | N-Terminal-pro-B-type Natriuretic Peptide(NT-proBNP) Heart failure Heart function Prognosis |
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