L—OHP联合5-Fu和CF治疗结直肠癌的临床观察

目的观察奥沙利铂（L—OHP）联合亚叶酸钙（CF）及氟尿嘧啶（5-Fu）方案治疗晚期结直肠癌的疗效及毒副反应。方法36例晚期结直肠癌患者应用5-Fu500mg/m^2，持续静脉滴注1～5d；CF200mg／m^2，1—5d，L—OHP130mg/m^2静脉滴入持续4h，1d；每3周重复1次。用药4个周期评价疗效。结果36例均可评价疗效。CR3例，PR15例，SD10例，总有效率为（CR＋PR）50％，临床受益率（CR＋PR＋SD）为77．78％；毒副反应主要是末梢神经毒性、恶心、呕吐及骨髓抑制等，多数反应较轻，无严重毒副反应发生。结论L—OHP联合CF及5-Fu治疗晚期结直肠癌疗效确切，毒副反应轻，明显改善生活质量。

Clinical efficacy of combined use of oxaliplatin and fluorouracil and calcium folinate in treatment of colorectal cancer

Aim To observe the clinical effect of combined use of oxaliplatin,fluorouracil and calcium folinate on advanced patients with colorectal cancer.Methods Thirty-six colorectal cancer patients at advanced stage were treatment with fluorouracil 500 mg/m2 by intravenous injection for 1-5days,and oxaliplatin 130mg/m2 for consecutive 4 hours per day and repeated use at three weeks interval,calcium folinate 200mg/m2,for 1-5days.The results were assessed for cycles later.Results bases on the score marks three cases ...