| 1,6-二磷酸果糖对自体肺体外循环中肺组织的保护作用 |
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| 引用本文： | 李跃萍,刘苏.1,6-二磷酸果糖对自体肺体外循环中肺组织的保护作用[J].中国热带医学,2011,11(7):872-873. |
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| 作者姓名： | 李跃萍 刘苏 |
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| 作者单位： | 海南医学院,海南医学院附属医院,海南海口,571101 |
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| 基金项目： | 海南省自然科学基金资助(No.808236) |
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| 摘 要： | 目的研究1，6-二磷酸果糖（FDP）在对抗自由基、细胞因子及维护肺脏组织结构方面对自体肺体外循环中肺的保护作用。方法将12只健康小猪随机分为2组，每组6只：对照组为自体肺体外循环组；实验组将FDP加入体外循环预充液中。两组体外循环均持续2h，于体外循环停机后检测肺组织肿瘤坏死因子—α、肺组织丙二醛的含量并观察术后两组肺组织的病理学变化。结果体外循环后实验组肺组织TNF—α与丙二醛含量明显低于对照组（P〈0．05），肺组织标本的光镜观察显示：实验组肺毛细血管淤血程度，中性粒细胞及淋巴细胞聚集程度，肺组织损伤程度均较对照组显著减轻。结论1，6-二磷酸果糖能明显降低自体肺体外循环术后肺组织自由基和TNF－α的含量，减轻肺组织损伤，对肺组织有明显的保护作用。
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| 关 键 词： | 1，6-二磷酸果糖 体外循环 丙二醛 肿瘤坏死因子-α |
The protective effects of fructose-1,6-diphosphate on lung tissues in autogenous oxygenator cardiopulmonary bypass |
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| LI Yue-ping,LIU Su.The protective effects of fructose-1,6-diphosphate on lung tissues in autogenous oxygenator cardiopulmonary bypass[J].China Tropical Medicine,2011,11(7):872-873. |
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| Authors: | LI Yue-ping LIU Su |
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| Institution: | LI Yue-ping,LIU Su.(Hainan Medical College,the affiliated hospital of Hainan Medical College Haikou 571100P.R.China) |
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| Abstract: | Aim To investigate the protective effects of fructose-1,6-diphosphate(FDP)In reducing lung injury induced by autogenous oxygenator cardiopulmonary bypass(CPB).Methods Twelve 12 piglets were randomly divided into control group consisted of 6 piglets and experimental group consisted of in which the FDP was added into the priming solution of cardiopulmonary bypass.The techniques of myocardium protection and cardiac arrest were the same in both groups.The autogenous oxygenator CPB was controlled running for 2 h... |
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| Keywords: | Fructose-1 6-diphosphate Cardiopulmonary bypass Malondialdehyde TNF-α |
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