宫颈癌及癌前病变细胞学筛查分析

目的比较巴氏手工涂片和液基薄层制片筛查对宫颈癌及癌前病变的应用价值。方法巴氏手工涂片和液基薄层制片按相关文献方法进行。结果巴氏手工涂片检查4965例，异常179例，宫颈病变发病率为3．6％，液基薄层制片法检查2022例，异常101例，宫颈病变发病率为5．0％，巴氏手工涂片发现宫颈病变发病率明显低于液基薄层制片法法，两者比较，差异有统计学意义（P〈0．05）；对L／SH和HISL的诊断准确率，液基薄层涂片为93．8％（15n6）和100．0％（19／19），与巴氏手工涂片的84．0％（21／25）和89．5％（17／19）相比，差异有统计学意义（P〈0．05）。结论巴氏手工涂片检测较液基薄层制片筛查宫颈癌及癌前病变简便，但时LISH和HISL期的病漏检明显，有条件单位应开展液基薄层制片筛查。

Value of two cytological methods in screening of cervical cancer

Aim To investigate the value of Papanicolaou smears and liquid-based thin-layer methods in screening of human papillomavirus(HPV).Methods Multinational cohort study with joint database analysis was conducted.There 24 295 women attending cervical screening were enrolled in HPV screening trials who had at least one cervical cytology or histopathology examination during follow-up.Results The cumulative incidence rate of cervical lesions was 3.6%(179/4 965)by Papanicolaou smears and 5.0% by liquid-based thin la...