肾上腺髓质素和内皮屏障功能

研究表明,内皮屏障功能丧失是急性炎症的标志,并且在严重感染中促成器官功能衰竭,但是目前还没有关于内皮屏障功能稳定性治疗方面的研究。内源性肽肾上腺髓质素（Adrenomedullin,AM）血清水平显示其在严重感染包括脓毒症和脓毒性休克时升高,在体内和体外脓毒症模型中用作有效的内皮屏障功能的稳定剂。AM还具有心血管保护作用,包括在炎症状态保护微循环。总之,AM可能作为一个有效的保护因素,通过保护内皮屏障功能防治严重感染中的心血管功能障碍。

Adrenomedullin and endothelial barrier function

Although loss of endothelial barrier function is a hall mark of every acute inflammation and contributes to fatal loss of organ function during severe infections,there is no sufficient therapy for stabilization of endothelial barrier function.Endogenous peptide adrenomedullin(AM) serum levels were shown to be increased during severe infection including sepsis and septic shock.In different in vitro and in vivo models AM acted as a potent therapeutic endothelial barrier function-stabilizing agent.Activation o...