| 慢性HBV感染者外周血T细胞亚群研究 |
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| 引用本文： | 吴涛,施理,林锋,贾杰,谢贤和.慢性HBV感染者外周血T细胞亚群研究[J].中国热带医学,2011,11(7):867-869. |
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| 作者姓名： | 吴涛 施理 林锋 贾杰 谢贤和 |
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| 作者单位： | 海南省人民医院感染科,海南海口,570311 |
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| 摘 要： | 目的分析健康人及慢性HBV感染者T细胞亚群特点，探讨宿主细胞免疫功能与慢性HBV感染临床转归的关系。方法使用流式细胞仪检测30名健康人及137例各型HBV感染者外周血T细胞亚群。结果1．对照组与各型HBV感染者的外周血T细胞亚群比较：从慢性HBV携带（CHBVC）组、慢性乙型肝炎（CHB）组到肝炎后肝硬化（PHBC）组，患者外周血CD3^＋T、CD4^＋T和CD8^＋T绝对值呈逐渐下降趋势，显著低于对照组（P〈0．05）。PHBC组CD4^＋T/CD8^＋T比值显著高于对照组和CHBVC组（尸〈0．05）。2．不同程度CHB组间外周血T细胞亚群比较：从CHB（轻度）组、CHB（重度）组到慢性重型乙型肝炎（CSUB）组，患者CD3^＋F、CD4^＋T、CD8^＋T绝对值和CD4^＋T／CD8^＋T比值逐渐下降。CSHB组CD3^＋T、CD4^＋T和CD8^＋T绝对值显著低于CHB（轻度）组（P〈0．05）。结论HBV慢性感染机制复杂，不同的临床转归患者T细胞亚群状态不同。慢性HBV感染后，肝脏损害程度严重的患者T细胞亚群功能低下及紊乱程度明显。
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| 关 键 词： | T细胞亚群 慢性乙型肝炎 慢性重型乙型肝炎 |
Study on function of T-lymphocyte subsets in peripheral blood of patients with chronic hepatitis B |
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| WU Tao,SHI Li,LIN Feng,et al..Study on function of T-lymphocyte subsets in peripheral blood of patients with chronic hepatitis B[J].China Tropical Medicine,2011,11(7):867-869. |
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| Authors: | WU Tao SHI Li LIN Feng |
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| Institution: | WU Tao,SHI Li,LIN Feng,et al.(Hainan Provincial People's Hospital,Haikou 570311,Hainan,P.R.China) |
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| Abstract: | Aim To analyse the function of T-lymphocyte subsets in healthy people and patients with chronic hepatitis B(CHB) and explore the correlation between the host cell immune function and clinical outcomes of chronic HBV infection.Methods T-lymphocyte subsets of 30 healthy people and 137 patients with CHB were detected by flow cytometry(FCM).Results The patients in CHBVC(chronic HBV and HBSAg carriers)group,CHB group and PHBC(posthepatitic B cirrhosis)group,peripheral blood T lymphocyte counts showed a gradual d... |
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| Keywords: | T-lymphocyte subsets Chronic hepatitis B chronic severe hepatitis B |
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