| 利培酮与氯氮平治疗慢性精神分裂症对照研究 |
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| 引用本文： | 谢宝钦,王占敏,韩秋利,边宏伟,苏秀茹,张海燕.利培酮与氯氮平治疗慢性精神分裂症对照研究[J].山东精神医学,2005,18(2):76-77. |
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| 作者姓名： | 谢宝钦 王占敏 韩秋利 边宏伟 苏秀茹 张海燕 |
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| 作者单位： | 河北省荣军医院
071000保定(谢宝钦，王占敏，韩秋利，边宏伟，苏秀茹)，河北省荣军医院 071000保定(张海燕) |
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| 摘 要： | 目的 了解利培酮治疗慢性精神分裂症的疗效及安全性。方法 将68 例慢性精神分裂症病人随机分为利培酮组和氯氮平组,每组各34例,进行为期8 周的对照研究,采用阳性与阴性症状量表(PANSS)及副反应量表(TESS)评定疗效及安全性。结果 利培酮有效率为64.7%,氯氮平为61.8%,两者疗效相当,无统计学差异(P>0.05)。利培酮对阴性症状的疗效优于氯氮平(P<0.05),利培酮的副作用较氯氮平少而轻。结论 利培酮是治疗慢性精神分裂症安全有效的药物。
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| 关 键 词： | 对照研究 利培酮 氯氮平治疗 副反应量表（TESS） 慢性精神分裂症病人 阳性与阴性症状量表 疗效及安全性 统计学差异 有效率 副作用 |
| 文章编号： | 1009-7201(2005)-02-0076-02 |
| 修稿时间： | 2005年1月22日 |
A control study of risperidone and colzapine in the treatment the chronic schizophrenia |
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| XIE Bao-qin,WANG Zhan-min,HAN Qiu-li,et al..A control study of risperidone and colzapine in the treatment the chronic schizophrenia[J].Shangdong Archives of Psychiatry,2005,18(2):76-77. |
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| Authors: | XIE Bao-qin WANG Zhan-min HAN Qiu-li |
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| Institution: | XIE Bao-qin,WANG Zhan-min,HAN Qiu-li,et al.Rongjun Hospital of Hebei,071000,China |
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| Abstract: | Objective To investigate the efficacy and safety of risperidone in the treatment of chronic schizophrenia.Methods Sixty eight patients with chronic schizophrenia,were randomly divided into two groups,risperidone group( n =34) or colzapine group( n =34) for 8 weeks.The PANSS and TESS were used for evaluating therapeutic and side effects.Results The therapeuic effect of risperidone was ideal.The effective rate of risperidone was 64.7%,and colzapine was 61 8%.There was no significant difference between the risperidone and colzapine( P >0.05).However,the efficacy of risperidone treatment of negative symptom was better than that of colzapine ( P <0.05).The side effects of risperidone was in the fewer than colzapine.Conclusion Risperidone is both effective and safe in the treatment of Chronic Schizophrenia. |
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| Keywords: | Risperidone Colzapine Schizophrenia |
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