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Prevention of fog-induced bronchospasm by nedocromil sodium
Authors:M. ROBUSCHI  A. VAGHI  P. SIMONE  S. BIANCO
Affiliation:Institute of Lung Diseases, University of Milan, Italy;Institute of Lung Diseases, University of Siena, Italy
Abstract:A single dose double-blind crossover study was performed to compare the efficacy of nedocromil sodium (4 mg) and placebo administered from pressurized aerosols against bronchoconstriction induced by the inhalation of ultrasonically nebulized distilled water (fog) in twelve asthmatic subjects. Neither active nor placebo pre-treatment produced any significant change in baseline FEV1 and SRaw. Nedocromil sodium significantly attenuated fog-induced falls in FEV1 ( P < 0.001) and increased specific airways resistance (SRaw, P < 0.01). The results provide further evidence of the potential therapeutic usefulness of nedocromil sodium in the management of chronic obstructive airways disease.
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