| NK/T细胞淋巴瘤中SYK的表达变化及意义 |
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| 引用本文： | 张 洁,肖胜军,宋铁山. NK/T细胞淋巴瘤中SYK的表达变化及意义[J]. 中国临床新医学, 2013, 6(5): 401-404 |
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| 作者姓名： | 张 洁 肖胜军 宋铁山 |
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| 作者单位： | [1]桂林医学院病理及病理生理学,广西541004 [2]桂林医学院附属医院病理科,广西541001 [3]湖北科技学院人体解剖学教研室,咸宁437100 |
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| 基金项目： | 广西自然科学基金资助项目（编号：桂科自0899015） |
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| 摘 要： | 目的探讨酪氨酸激酶（SYK）在NK／T细胞淋巴瘤中的表达及意义。方法应用免疫组织化学（SP）法检测SYK在外周NK／T细胞淋巴瘤组织标本中的表达情况，并分析其表达与年龄、性别、分期及细胞增殖指数等临床病理参数的关联性。结果SYK在NK／T细胞淋巴瘤中高表达率为27．27％（15／55）；低表达率为72．73％（40／55），且与临床分期和细胞增殖指数有关。SYK高表达者具有较高的肿瘤分期和增殖指数。结论NK／T细胞淋巴瘤中SYK表达上调与细胞增殖及临床分期有关，是其潜在的诊断和预后标记。
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| 关 键 词： | 外周T细胞淋巴瘤 SYK 免疫组织化学 |
| 收稿时间： | 2013-01-15 |
SYK expression in NK/T cell lymphoma and its significance |
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| ZHANG Jie,XIAO Sheng-jun,SONG Tie-shan. SYK expression in NK/T cell lymphoma and its significance[J]. Chinese Journal of New Clinical Medicine, 2013, 6(5): 401-404 |
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| Authors: | ZHANG Jie XIAO Sheng-jun SONG Tie-shan |
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| Affiliation: | ZHANG Jie, XIAO Sheng-jun, SONG Tie-shah. (Department of Pathology, Guilin Medical University, Guangxi 541004, China) |
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| Abstract: | Objective To investigate the expression of SYK in NK/T cell lymphomas and its significance. Methods The expression of SYK in NK/T cell lymphoma was examined by immunohistochemisty assay to evaluate the relation between it＇s expression and clinicopathological characters such as age, sex, stage and proliferation index. Results The percentage of NK/T-cell lymphoma with high expression of SYK was 27. 27% （ 15/55 ）. That with low expression of SYK was 72.73% （40/55）. The expression of SYK was associated with tumour stage and cell prolifera- tion index. NK/T lymphoma with high SYK expression had higher stage and proliferation index. Conclusion SYK overexpression is associated with tumour stage and cell proliferation in NK/T cell lymphomas, and is a potential diag nostic and prognostic factor. |
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| Keywords: | Peripheral T-cell lymphomas SYK Immunohistochemisty |
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