经鼻持续气道正压通气在早产儿呼吸窘迫综合征中应用探讨

目的探讨早期应用经鼻持续气道正压通气（NCPAP）在早产儿呼吸窘迫综合征中的应用效果。方法选取91例早产儿随机分为两组，实验组患儿在出生后出现缺氧即予以NCPAP进行呼吸管理，对照组患儿只有在吸氧浓度（Fi02）〉40％，经皮血氧饱和度（TcSO：）波动于85％-88％时予以NCPAP。观察两组有创机械通气率、院内感染发生率和慢性肺疾病发生率。结果实验组有创机械通气率为32．65％，对照组为59．52％，实验组低于对照组（P〈0．05）；实验组院内感染率（12．24％）也低于对照组（30．95％）（P〈0．05）；慢性肺疾病发生率（8．16％）也低于对照组（23．81％）（P〈0．05）。结论早产儿呼吸窘迫综合征患儿早期应用NCPAP可明显降低有创机械通气、院内感染和慢性肺疾病的发生率。

Anaiysis on the application of nasal continuous positive airway pressure in the premature infant with respiratory distress syndrome

Objective To investigate the role of early nasal continuous positive airway pressure （NCPAP）in the premature infant with respiratory distress syndrome （RDS）. Methods A total of 91 premature infant with RDS were divided into two groups randomly. In the experimental group （ n = 49） NCPAP was started when oxygen deficien- cy occurred; in the control group （ n = 42） NCPAP was started when the concentration of oxygen inhalation （ FiO2 ） was 〉 40% and transcntaneous oxygen saturation between 85% and $8%. The rate of mechanical ventilation, the rate of hospital infection and the rate of the chronic lung disease were observed. Results The rate of mechanical ventilation （32. 65% ） in the experimental group was lower than that（59.52% ）in the control group, so a significant difference existed between them（P 〈0. 05） ;the rate of hospital infection（ 12.24% ） in the experimental group was lower than that（30. 95% ）in the control group（P 〈0. 05） ;the rate of chronic lung disease （8. 16% ） in the experimental group was lower than that （23.81% ） in the control group （ P 〈 0.05 ）. Conclusion Using early NCPAP in the premature in- fant with respiratory distress syndrome can reduce the rate of mechanical ventilation, the rate of hospital infection and the rate of chronic lung disense obviously.