广西2008年一起甲型肝炎暴发流行株基因分型研究 |
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引用本文: | 陈敏玫,周开姣,莫兆军,谭毅,李海,杨进业. 广西2008年一起甲型肝炎暴发流行株基因分型研究[J]. 中国热带医学, 2009, 9(12): 2219-2220 |
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作者姓名: | 陈敏玫 周开姣 莫兆军 谭毅 李海 杨进业 |
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作者单位: | 广西壮族自治区疾病预防控制中心,广西,南宁,530028 |
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摘 要: | 目的了解2008年广西一起甲型肝炎暴发流行株基因型。方法采自甲型肝炎暴发流行中3所学校现症病人的血清。经RT-PCR对HAV-VP1区核苷酸进行扩增和序列分析。结果来自3所学校的HAV流行株VP1区核苷酸序列同源性为100%,与AH2株的同源性最高,为98.6%,同属于IA亚型;氨基酸水平上没有发生氨基酸的缺失、插入,未发生有意义的突变。结论IA亚型是导致此次甲肝暴发的流行株,3所学校具有相同的传染源和流行株。人群甲肝疫苗免疫水平低是甲肝流行的主要因素,应加强甲肝疫苗的免疫水平及甲肝分子流行病学监测。
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关 键 词: | 甲型肝炎病毒 基因型 暴发流行 |
Genotyping of wild-type hepatitis a virus isolated in an outbreak of HAV in Cuangxi,2008 |
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Affiliation: | CHEN Min-mei, ZHOU Kai-jiao,MO Zhao-jun,et al. (Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning 530028, Guangxi, P. R. China) |
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Abstract: | Objective To investigate the genotypes of wild-type hepatitis a virus isolated in an outbreak of HAV in Guangxi,2008. Methods All serum specimens were the nucleotide sequence of VP1 region amplified by RT-PCR. Results All 3 isolated in the outbreaks belonged to genotype I and subtpye IA,the identity were as high as 100%. Conclusion All the isolated wild-type HAV strains in the outbreak were subtype IA. |
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Keywords: | Hepatitis A Virus Genotype Outbreaks |
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