| 糖尿病大鼠组织的蛋白酪氨酸磷酸酶活性变化 |
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| 引用本文： | 朱宁,田恩江,汤新之.糖尿病大鼠组织的蛋白酪氨酸磷酸酶活性变化[J].天津医药,2000,28(10):610-611. |
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| 作者姓名： | 朱宁 田恩江 汤新之 |
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| 作者单位： | 1. 300070,天津医科大学生化教研室
2. 天津市内分泌研究所 |
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| 基金项目： | 天津市自然科学基金资助课题 |
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| 摘 要： | 目的：研究蛋白酪氨酸磷酸酶（ＰＴＰａｓｅ）与胰岛素抵抗的关系。方法：链脲佐菌素（ＳＴＺ）诱发大鼠糖尿病，ＥＬＩＳＡ法测定糖尿病大鼠各组织器官的ＰＴＰａｓｅ活性，并与正常大鼠进行比较。结果：ＳＴＺ－糖尿病大鼠肝脏和骨骼肌的ＰＴＰａｓｅ活性升高分别为７８％和５０％。结论：胰岛素靶细胞的ＰＴＰａｓｅ活性变化与胰岛素抵抗的病因密切相关。
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| 关 键 词： | 糖尿病 蛋白酪氨酸磷酸酶 链脲菌素 |
Alteration of Protein Phosphotyrosine Phosphatase Activity in Tissues of Diabetic Rats |
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| ZHU Ning,TIAN Enjiang,TANG Xinzhi.Alteration of Protein Phosphotyrosine Phosphatase Activity in Tissues of Diabetic Rats[J].Tianjin Medical Journal,2000,28(10):610-611. |
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| Authors: | ZHU Ning TIAN Enjiang TANG Xinzhi |
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| Institution: | ZHU Ning
,TIAN Enjiang
,TANG Xinzhi
;(Department of Biochemistry, Tianjin Medical University 300070) |
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| Abstract: | Objective:To study the relation between protein phosphotyrosine phosphatase(PTPase)and insulin resistance. Meth-ods:PTPase activities were measured from streptozotocin(STZ)-induced diabetic rat and normal rat tissues using ELISA. Results:PTPase activities increased by 78% and 50% in liver and skeletal muscle of STZ-induced diabetic rats respectively. Conclusion:Changes of PTPase activities in insulin target tissues will be related to the cause of insulin resistance. |
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| Keywords: | streptozocin diabetes mellitus experimental rats protein-tyrosine-phosphatase enzyme-linked im- munosorbent assay insulin resistance |
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