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| 载脂蛋白与早期糖尿病肾病相关性研究 | |
| 引用本文： | 刘静芹,刘莉,宗燕军. 载脂蛋白与早期糖尿病肾病相关性研究[J]. 中国慢性病预防与控制, 2011, 19(1): 62-63 |
| 作者姓名： | 刘静芹 刘莉 宗燕军 |
| 作者单位： | 1. 保定市第一医院,内分泌科,河北,071000 2. 保定市疾病预防控制中心,内科 3. 保定市急救中心,内科 |
| 摘 要： | 目的探讨血清载脂蛋白浓度变化与糖尿病肾病（DN）进展之间的关系。方法将837例2型糖尿病患者分为单纯糖尿病（SDM）组524例、早期糖尿病‘肾病（EDN）组208例和临床糖尿病肾病（CDN）组105例,分别测定血清载脂蛋白水平,并与正常对照组比较。结果SDM组血清载脂蛋白浓度（APOA1、APOA,／B100）与正常对照组比较差异无统计学意义。EDN、CDN组血清APOA1、APOA1／B100浓度明显低于正常对照组和SDM组（P〈0．01）。SDM组血清载脂蛋白B100（APOB100）浓度明显高于正常对照组,CDN组APOB100。水平明显高于SDM、EDN组（P〈0．01）。尿白蛋白排泄率（UAER）与血清APOA1、APOA1／B100浓度呈直线负相关（r=-0．1765,P=0．011;r=-0．2018,P=0．0034）,与APOB,00浓度呈直线正相关（r=0．2216,P=0．0013）。结论2型糖尿病患者随着尿UAER逐渐升高,血清APOA1、APOA1／B100逐渐下降,APOB100逐渐升高,提示血清载脂蛋白水平与DN进展有关。 |
| 关 键 词： | 糖尿病肾病 载脂蛋白A1 APOA1／B100 载脂蛋白B100 尿白蛋白排泄率 |
Clinical Study on Relationship between Apolipoprotein and Early Diabetic Nephropathy |
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| LIU Jing-qin,LIU Li,ZONG Yan-jun. Clinical Study on Relationship between Apolipoprotein and Early Diabetic Nephropathy[J]. Chinese Journal of Prevention and Control of Chronic Non-Communicable Diseases, 2011, 19(1): 62-63 | |
| Authors: | LIU Jing-qin LIU Li ZONG Yan-jun |
| Affiliation: | LIU Jing-qin,LIU Li,ZONG Yan-jun.Department of Endocrinology,The First Hospital of Baoding Municipality,Baoding 071000,China |
| Abstract: | Objective To investigate the relationship between apolipoprotein levels and evolution of diabetic nephropathy (DN).Methods 837 patients with type 2 diabetes mellitus (T2DM) were divided into 3 groups according to the Mogensen criterion of DN:524 simple diabetes mellitus (SDM),208 with microalbuminuria (EDN) and 105 with clinical albuminuria (CDN).Apolipoprotein was tested in all of them,and compared with control group.Results Apolipoprotein A1(APOA1)and apolipoprotein A1/apolipoprotein B100 (APOA1/B100) lev... |
| Keywords: | APOA1/B100 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |