无先兆偏头痛危险因素的病例对照研究

目的探讨无先兆偏头痛(MO)的危险因素。方法使用现场问卷调查的方法 ,以天津医科大学总医院、天津中医药大学第二附属医院2004年11月—2006年3月确诊的MO患者为病例组,按性别、年龄±3岁选取医院其他科室的非MO患者作为对照组,进行1:2匹配的病例对照研究。结果单因素分析结果表明,体力劳动者(OR=0.180,95%CI:0.082～0.396)、体质指数(BMI)高(OR=4.177,95%CI:1.978～8.819)、偏头痛家族史(OR=6.500,95%CI:2.119～19.935)、脑血管病家族史(OR=4.357,95%CI:2.1470～8.8420)、睡眠质量(OR=0.411,95%CI:0.256～0.661)、喜甜食(OR=6.488,95%CI:2.651~15.74)、经常性内心情感体验(OR=12.691,95%CI:4.435～36.318)及工作和生活上的不良应激事件(OR=6.667,95%CI:1.835～24.224)与MO的关联有统计学意义(P0.05)。多因素分析结果显示,体力劳动(OR=0.143,95%CI:0.034～0.601)、BMI(OR=5.226,95%CI:1.350～20.229)、睡眠质量(OR=0.295,95%CI:0.124～0.701)及有经常性内心情感体验(OR=9.897,95%CI:2.080～47.091)与MO的关联有统计学意义(P0.05)。结论 MD的发生是多因素综合作用的结果 。

A 1:2 Matched Case-control Study of Risk Factors for Migraine without Aura

Objective To identify risk factors for migraine without aura （MO）. Methods The diagnosed MO patients, from the General Hospital of Tianjin Medical University and the Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine during Nov. 2004 to Mar. 2006, were as cases, while non-MO patients from other departments as controls with 1：2 matched by sex and age （±3yrs）. The questionnaires were collected in hospital. Results Univariate analysis showed that manual workers （OR =0.180, 95% CI： 0.082 -0.396）, higher BMI （OR =4.177, 95% CI： 1.978-8.819）, family history of migraine and cerebrovascular diseases （ OR =6.500, 95% CI： 2.119-19.935; OR =4.357, 95% CI： 2.1470-8.8420）, good quality of sleep （OR = 0.411, 95%CI： 0.256-0.661）, sweets （0R=6.488, 95%CI：2.651-15.74）, recurrent inner emotional experience and adverse events in work or living （OR=12.691, 95%CI： 4.435-36.318; OR=6.667, 95%CI： 1.835-24.224） were associated with MO. Multivariate analysis showed that manual workers （OR=0.143, 95%CI： 0.034-0.601）, higher BMI （OR=5.226, 95%CI： 1.350-20.229）, good quality of sleep （OR=0.295, 95%CI： 0.124-0.701）, recurrent sentiment experience （OR=9.897, 95%CI： 2.080-47.091） were associated with MO. Conclusion MO occurred as the result of multiple risk factors and it should be paid more attention to prevent against MO.