糖尿病与原发性肝癌关系的病例对照研究Meta分析

目的评价糖尿病(DM)在导致原发性肝癌(HCC)的危险因素中所起的作用,探讨DM和HCC的关系。方法通过制定检索策略,计算机检索Cochrane Library、PubMed、EMbase、Ovid、中国生物医学文献、维普中文科技期刊和清华同方等数据库;检索时间均从建库至2008年12月。纳入所有研究DM和HCC病因相关性的病例-对照研究,并对纳入的文献进行评价。采用Revman5.0软件对同质研究进行Meta分析。结果最终有14篇病例-对照研究纳入系统评价。在纳入的14篇病例-对照研究中,12篇纳入Meta分析,HCC组与对照组的人群比较Meta分析结果显示,合并效应量OR=2.0,95%CI=1.42~2.81,表明暴露DM发生HCC的危险性是未暴露DM的2.0倍。结论 DM与HCC存在正关联,提示DM可能是HCC的一个独立致病危险因素。

The Association between Diabetes Mellitus and Hepatocellular Carcinoma: A Meta-analysis of Case-control Study

Objective To evaluate the association between diabetes mellitus （DM） and hepatocellular carcinoma （HCC）. Methods Original literatures for this review were searched with databases of Cochrane Library, PubMed, EMbase, Ovid and CBMdisc, etc. from databases establishment to December 2008. All the case-control studies on the association between DM and HCC were included and the quality of them was assessed. Meta-analysis was conducted using the Cochrane Collaboration＇s RevMan 5.0 software. Results A total of 14 case-control studies were included. Out of 14 case-control studies, 12 met the inclusion criteria for Meta-analysis. As compared with the control group, the results of HCC group by Meta-analysis showed that the pooled odds ratio （OR） was 2.0 and 95% confidence interval （95%CI） was1.42-2.81. Conclusion Our analysis showed a positive association between DM and HCC.