女性系统性红斑狼疮发病危险因素的病例对照研究

目的探讨系统性红斑狼疮(SLE)发病的相关危险因素,为SLE的病因学研究及一级预防提供理论依据。方法采用病例-对照研究方法 ,选取天津医科大学总医院感染免疫科121例SLE患者及妇科122例对照者进行问卷调查,采用非条件Logistic回归进行危险因素分析。结果单因素Logistic回归分析结果显示,居住环境潮湿(OR=3.60,95%CI:1.39~9.36)、其他结缔组织病(OR=14.88,95%CI:3.43~64.52)、药物过敏(OR=9.52,95%CI:3.58~25.31)、日光过敏(OR=9.78,95%CI:4.61~84.92)、扁桃腺炎(OR=4.06,95%CI:2.14~7.72)、不明原因发热(OR=33.06,95%CI:9.95~109.79)、流产手术(OR=7.53,95%CI:3.09~18.36)、绝育手术(OR=30.04,95%CI:3.88~232.92)、经量(OR=2.00,95%CI:1.08~3.69)、出生时母亲的年龄(OR=1.08,95%CI:1.02~1.15)、减肥(OR=3.57,95%CI:1.26~10.07)、工作应激事件(OR=25.41,95%CI:0.36~192.22)、接受家庭批评(OR=0.41,95%CI:0.27~0.62)与SLE的发病有统计学意义。多因素Logistic回归分析显示,其他结缔组织病(OR=12.12,95%CI:1.79~82.04)、药物过敏(OR=5.95,95%CI:1.73~20.52)、日光过敏(OR=21.91,95%CI:4.08~117.54)、不明原因发热(OR=27.53,95%CI:7.11~106.59)、流产手术(OR=4.87,95%CI:1.69~14.04)、工作应激事件(OR=18.72,95%CI:1.76~198.74)、居住环境潮湿(OR=6.42,95%CI:1.79~23.05)是SLE的影响因素。结论 SLE是一种反复发作的自身免疫性疾病,其病因复杂,因此,尽早明确其致病相关影响因素,对今后制定该病的相关防治措施意义重大。

A Case-control Study on the Risk Factors for Systemic Lupus Erythematosus in Women

Objective To investigate the relative risk factors for SLE in women. Methods A case-control study was conducted on 121 female case with SLE and 122 female controls without SLE from gynecology department between Jan. and Dec. of 2006 from the general hospital of Tianjin Medical University, using unconditional Logistic regression model to analyze the relative risk factors. Results Univariate unconditional Logistic regression model showed that damp living environment （OR=3.60, 95%CI：1.39-9.36）, other connective tissue disorder （OR=14.88, 95%CI：3.43-64.52）, drug allergy （OR=9.52, 95%CI：3.58-25.31）, Sun allergy （OR=9.78, 95%CI：4.61-84.92）, tonsillitis （OR=4：06, 95%CI：2.14-7.72）, Fever of unknown origin （OR=33.06, 95%CI： 9.95-109.79）, induced abortion （OR =7.53, 95%CI：3.09 -18.36）, sterilization operation （OR =30.04, 95%CI：3.88-232.92）, menstrual blood volume （OR=2.00, 95%CI： 1.08-3.69）, mother＇s age at birth （OR=1.08, 95%Ch 1.02-1.15）, weight loss （OR =3,57, 95%CI：1.26-10.07）, work stress events （OR=25.41, 95%CI：0.36-192.22）, accept family criticism （OR=0.41, 95%CI：0.27-0.62） were associated with SLE. Multivariate unconditional Logistic regression model in total significant factors showed that the risk factors for SLE included other connective tissue disorder （OR=12.12, 95%CI：1：79-82.04）, drug allergy （OR=5.95, 95% CI：1.73- 20.52）, sun allergy （OR=21.91, 95%CI：4.08-117.54）, fever of unknown origin （OR=27.53, 95%CI：7.11-106.59）, induced abortion （OR=4.87, 95%CI： 1.69-14.04）, work stress events（OR=18.72, 95%CI：1.76-198.74）, damp living environment（OR=6.42, 95%CI： 1.79-23.05）. Conclusion SLE is a recurrent autoimmune disease and its causes are very complex. Therefore, it is significant to clarify its etiology-related factors for making prevention and control measures.