| 舒洛地特联合缬沙坦对高血压肾损害患者肾功能和尿蛋白的影响 |
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| 引用本文： | 王颖,燕树勋. 舒洛地特联合缬沙坦对高血压肾损害患者肾功能和尿蛋白的影响[J]. 中国慢性病预防与控制, 2011, 19(3): 282-283 |
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| 作者姓名： | 王颖 燕树勋 |
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| 作者单位： | 1. 郑州大学第一附属医院,老年科,河南,450000
2. 河南中医学院第一附属医院,内分泌科 |
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| 摘 要： | 目的观察舒洛地特联合缬沙坦治疗对高血压肾损害患者肾功能和尿蛋白的影响。方法60例高血压肾损害患者均进行基础治疗,然后随机分为两组,对照组30例,每天晨服缬沙坦胶囊80mg;治疗组30例,在对照组治疗基础上加服舒洛地特胶囊250LSU,每日2次。两组疗程均为3个月。检测治疗前后血肌酐（Scr）、尿素氮（BUN）、血尿酸（uA）、血清光抑素C（cystatin C）、24h尿蛋白、尿β2－微球蛋白（β2－MG）、尿旺。微球蛋白（α1－MG）、尿N－乙酰－β－D葡萄糖苷酶（NAG）。结果与治疗前相比,两组治疗后BUN、Cr、UA无明显变化（P〉0．05）,cystatinC均明显减少（P〈0．01）,而治疗组血cvstatin C减少更加明显（P〈O．01）;两组治疗后24h尿蛋白定量、尿α1－MG、β2－MG、NAG均明显减少（P〈O．01）,而治疗组24h尿蛋白定量、尿仪。α1－MG、β2－MG、NAG减少更加咀显（P〈0．01）。结论舒洛地特联合缬沙坦治疗比单纯应用缬沙坦治疗能够更有效地降低2型糖尿病肾病患者的尿蛋白,对肾脏具有良好的保护作用。
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| 关 键 词： | 高血压 肾损害 舒洛地特 缬沙坦 |
The Effects of Sulodexide plus Valsartan on Renal Function and Uric Protein in Hypertensive Patients with Renal Impairment |
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| WANG Ying,YAN Shu-xun. The Effects of Sulodexide plus Valsartan on Renal Function and Uric Protein in Hypertensive Patients with Renal Impairment[J]. Chinese Journal of Prevention and Control of Chronic Non-Communicable Diseases, 2011, 19(3): 282-283 |
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| Authors: | WANG Ying YAN Shu-xun |
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| Affiliation: | WANG Ying,YAN Shu-xun.Department of Geriatrics,The First Affiliated Hospital,Zhengzhou University,Zhengzhou 450000,China |
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| Abstract: | Objective To observe the effects of the combination therapy of sulodexide and valsartan on renal function and uric protein in hypertensive patients with renal impairment.Methods Sixty senile hypertensive patients with renal impairment were randomly divided into control group(n=30,routine treated with valsartan 80 mg/d in the morning) and sulodexide group(n=30,routine treated with valsartan 80 mg/d in the morning and sulodexide 250LSU,bid) for 3 months study.At the end of the study,serum creatinine(Scr),bloo... |
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| Keywords: | Hypertension Renal impairment Sulodexide Valsartan |
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