| 槐定碱对大鼠海马齿状回突触传递的影响 |
| |
| 引用本文： | 侯延辉,彭晓东,陆钊罡,王锐. 槐定碱对大鼠海马齿状回突触传递的影响[J]. 宁夏医科大学学报, 2011, 0(8): 718-721 |
| |
| 作者姓名： | 侯延辉 彭晓东 陆钊罡 王锐 |
| |
| 作者单位： | 宁夏医科大学药学院;宁夏回药现代化工程技术研究中心;宁夏医科大学基础医学院; |
| |
| 基金项目： | 宁夏回族自治区自然科学基金(NZ0785) |
| |
| 摘 要： | 目的观察槐定碱对麻醉大鼠海马齿状回突触传递活动的影响。方法采用急性埋藏电极记录麻醉大鼠海马齿状回诱发电位的方法,以群峰电位（PS）幅度和群体兴奋性突触后电位（pEPSP）斜率为观察指标,观察腹腔注射槐定碱（3.0、6.0、12.0 mg·kg^-1）对基础突触传递和高频刺激诱导长时程增强（LTP）诱导的影响。结果槐定碱能够明显增大基础突触传递的诱发电位PS幅值且不呈剂量依赖关系,但对pEPSP slope没有影响;能够促进条件刺激引发的pEPSP斜率LTP现象且不呈剂量依赖关系,但对PS幅度没有影响。结论槐定碱对基础突触传递过程中海马齿状回（DG）颗粒细胞的兴奋性有促进作用,但对大鼠内侧穿行通路（MPP）-DG通路形成的突触联系过程没有影响;对高频刺激诱发LTP后突触后颗粒细胞的兴奋性没有影响,但对高频刺激诱发LTP后的突触传递过程有促进作用。
|
| 关 键 词： | 槐定碱 海马齿状回 突触传递 长时程增强 群峰电位 |
Effects of Sophoridine on Synaptic Transmission in the Dentate Gyrus of Anesthetized Rats |
| |
| HOU Yan-hui,,PENG Xiao-dong,,LU Zhao-gang,WANG Rui. Effects of Sophoridine on Synaptic Transmission in the Dentate Gyrus of Anesthetized Rats[J]. Journal of Ningxia Medical College, 2011, 0(8): 718-721 |
| |
| Authors: | HOU Yan-hui PENG Xiao-dong LU Zhao-gang WANG Rui |
| |
| Affiliation: | HOU Yan-hui1,2,PENG Xiao-dong2,3,LU Zhao-gang,WANG Rui2,3(1.School of Pharmacy,Ningxia Medical University,Yinchuan 750004,2.Ningxia Engineering & Technology Research Center for Modernization of Hui Medicine,3.School of Basic Medicine,Yinchuan 750004) |
| |
| Abstract: | Objective To investigate the effects of sophoridine on synaptic transmission in the dentate gyrus of anesthetized rats.Methods Perforant path evoked field potentials were recorded in the dentate gyrus by acutely implanted electrodes.Two parameters,the slope of population excitatory postsynaptic potential(pEPSP slope) and the amplitude of population spike(PS amplitude),were employed to evaluate the effects of drug.LTP was induced by high-frequency stimulation(60 pulses at 60 Hz) 30 min after intraperitoneal ... |
| |
| Keywords: | sophoridine hippocampal dentate gyrus synaptic transmission long-term potentiation population spike |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
