Thromboxane and prostacyclin release in adult respiratory distress syndrome |
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Authors: | G. Deby-Dupont M. Braun M. Lamy C. Deby J. Pincemail M. E. Faymonville P. Damas L. Bodson M. P. Lecart R. Goutier |
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Affiliation: | (1) Laboratory of Biochemistry and Radiobiology, Institut de Chimie, B6, University of Liège, Liège, Belgium;(2) Department of Anaesthesiology, University Hospital, Liège, Belgium |
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Abstract: | Plasma thromboxane B2 (TXB2) and 6-ketoprostaglandin F1 (6-keto-PGF1) were measured in 84 patients at risk of developing adult respiratory distress syndrome (ARDS) (44 patients following multiple trauma, 29 patients following abdominal surgery and 11 patients with acute pancreatitis). Forty-nine of these 84 patients developed an ARDS. High (>140 pg/ml plasma) TXB2 values were found in 52/84 patients. The median values of TXB2 were: 360 pg/ml in multiple injured, 250 pg/ml in abdominal surgery and 410 pg/ml in acute pancreatitis patients. The median TXB2 value was 575 pg/ml in patients developing ARDS and 140 pg/ml in those without this complication: this difference was statistically significant (p<0.05). The median values of 6-keto-PGF1 were 55pg/ml in multiple injured, 25 pg/ml in abdominal surgery and 120 pg/ml in acute pancreatitis patients. The median 6-keto-PGF1 value was 122 pg/ml in ARDS patients and 25 pg/ml in non-ARDS patients (statistically significant: p<0.05). High TXB2 and 6-keto-PGF1 values were particularly related to sepsis in abdominal surgery patients (p<0.05) and in multiple injured patients (p<0.01). No relation could be established between abnormal TXB2 or 6-keto-PGF1 values and death. High TXB2 values often persisted for several days and were observed particularly at the time ARDS diagnostic criteria were fulfilled. An imbalance between TXB2 and 6-keto-PGF1 was observed: 6-keto-PGF1 values were always lower than TXB2 values and did not persist for more than 24 h except in four cases. Our data demonstrate a significant production of prostanoids in ARDS patients particularly in sepsis and indicate a disturbance in balance of the prostacyclin/thromboxane axis. |
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Keywords: | Adult respiratory distress syndrome Thromboxane B2 6-keto-PGF1 /content/l2644484n812713t/xxlarge945.gif" alt=" agr" align=" BASELINE" BORDER=" 0" > Sepsis |
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