柴胡陷胸汤加减治疗2型糖尿病合并脂肪性肝炎临床观察

目的观察柴胡陷胸汤加减对2型糖尿病（T2DM）合并非酒精性脂肪性肝炎（NASH）的治疗效果。方法将门诊49例确诊为T2DM合并NASH的患者随机分成治疗组和对照组，治疗组26例，对照组23例。两组均接受饮食控制、运动及阿卡波糖与水飞蓟宾胶囊降糖、保肝治疗，治疗组在此基础上加服中药颗粒柴胡陷胸汤加减。两组疗程均为3个月，观察两组患者治疗前与治疗后证候积分情况及血糖、血脂、肝功能指标，并进行疗效比较。结果两组患者治疗前后证候积分比较，差异均有统计学意义（P〈0．01），治疗组优于对照组（P〈0．05）；两组患者治疗前后血糖、血脂、肝功能指标等比较，差异均有统计学意义（P〈0．05），治疗组优于对照组（P〈0．05）。治疗组总有效率优于对照组（P〈0．05）。结论柴胡陷胸汤加减治疗T2DM合并NASH有效，安全性好，值得临床推广应用。

Clinical Observation of Type 2 Diabetes Mellitus Complicated with Steato hepatitis Treated with Modified Chaohu Xianxiong Decoction

Objective To observe the therapeutic effect of modified Chaihu Xianxiong Decoction on type 2 diabetes mellitus （ T2DM ） complicated with non - alcoholic steatohepatitis （ NASH ）. Methods Forty - nine outpatients of T2DM complicated with NASH were randomized into a treatment group（26 cases） and a control group（23 cases）. The diet control, physical exercise, anti -glucose with Acarbose and Silybin Cap sule, and liver protection were applied in the two groups. In the treatment group, besides the basic treatment, the Chinese medicine granules, modified Chaihu Xianxiong Decoction were supplemented for oral administra tion. The duration of treatment was 3 months. The symptom score, blood glucose, blood lipid and the indexes of liver function were observed before and after treatment in the two groups. The efficacy was compared. Re sults The difference in the symptom score before and after treatment was significant in the patients of two groups （P 〈 0.01 ）, the result in the treatment group was better than that in the control group （P 〈 0.05 ）. The differences in blood glucose, blood lipid and the indexes of liver function were significant before and after treatment in the patients of two groups（P 〈0.05）. The results in the treatment group were superior to those in the control group （ P 〈 0.05 ）. The total effective rate in the treatment group was higher than that in the control group（P 〈 0.05 ）. Conclusion The modified Chaihu Xianxiong Decoction is effective and safe in treatment of T2DM complicated with NASH and deserves to be promoted in clinical practice.