骨骼肌兴奋收缩偶联与细胞内的钙稳态★

背景：在骨骼肌胞浆内，Ca2+是神经兴奋和肌肉收缩之间的重要偶联因子，控制着肌肉收缩的启动和舒张的终止，对骨骼肌的兴奋收缩偶联起着不可或缺的作用，骨骼肌的兴奋收缩偶联与细胞内钙稳态的变化紧密相关。 目的：研究近年来骨骼肌细胞内钙调控机制的研究进展及钙稳态与运动之关系的进展。 方法：电子检索CNKI数据库、读秀学术搜索等中文数据库和Elsevier SD，Springer Link等英文数据库1980/2010收录的骨骼肌兴奋收缩偶联和钙稳态的相关综述和实验研究报告，分析骨骼肌细胞内钙调控机制的研究进展及钙稳态与运动之关系的研究进展。 结果与结论：共纳入骨骼肌兴奋收缩偶联与钙稳态相关文献43篇。骨骼肌的兴奋收缩偶联与细胞内钙稳态之间有着密不可分的关系，但骨骼肌内钙稳态的调控机制还不甚明朗，尚期待大量研究。对运动与肌细胞内钙稳态的关系的研究也仍需要进一步努力，探索适宜适当的运动，探索运动性疲劳的发病机制，有效预防和对抗运动性疲劳及肌肉损伤仍将是研究者的工作重点。

Excitatin-contraction coupling and intracellular calcium homeostasis in skeletal muscles

BACKGROUND: Ca2+ acts as an essential intracellular signal in the process of excitation-contraction coupling in inner skeletal muscles. The excitatin-contraction coupling is closely associated with intracellular calcium homeostasis in skeletal muscles. OBJECTIVE: To review the research progresses on the mechanisms of calcium controlling in skeletal muscles and the interrelationship between intracellular calcium homeostasis and exercises. METHODS: A computer online search was performed to find papers published between 1980 and 2010 in databases of CNKI, Duxiu academic search, Elsevier SD and Springer Link. Documents concerning skeletal muscle excitatin-contraction coupling and calcium homeostasis were included to analyze the interrelationship between intracellular calcium homeostasis and exercises. RESULTS AND CONCLUSION: A total of 43 literatures were included in this study. There were closely relationships between intracellular calcium homeostasis and exercises. However, controlling mechanisms of intracellular calcium homeostasis remain poorly understood. The precise relationship between sports and calcium homeostasis needs further explored. How to exercise properly, what are the pathogenesis of sports fatigue, and how to prevent and anti-sports fatigue or muscle injury are the research focuses.