HLA-Bw54 (Bw22-J, J-1) Antigen in Juvenile Onset Diabetes Mellitus in Japan |
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| Authors: | Kyoko Okimoto Takeo Juji Shuntaro Ishiba Hiroshi Maruyama Hiroshi Tohyama Kinori Kosaka |
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| Affiliation: | The Third Department of Internal Medicine, Faculty of Medicine;Blood Transfusion Service, University of Tokyo;Department of Pediatrics, Tokyo Women's Medical College, Tokyo, Japan |
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| Abstract: | HLA—B8 and/or Bw15, associated with juvenile onset insulin-dependent diabetes mellitus (JDM) in Caucasians, have a very low frequency in the Japanese population. Thus, we were interested in investigating the association between JDM and HLA antigen in a Japanese population. Eighty-nine patients with JDM and 128 unrelated random controls were HLA-typed by the micro-lymphocytotoxicity test. The data revealed a significant, positive association between this type of diabetes mellitus and HLA-Bw54 (Bw22-J, J-1) antigen (Japanese-specific split antigen of HLA—Bw22). |
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