2007—2011年佛山市澜石社区非酒精性脂肪性肝病肝因性死亡情况调查

目的对佛山市澜石社区非酒精性脂肪肝(non-alcoholil fatty liver disease,NAFLD)相关肝因性死亡状况进行调查,为社区防治提供依据。方法采用回顾性调查的方法通过国家"死亡病例网络报告系统"收集2007—2011年5年间社区总死亡病例,结合医院的住院病案,筛选出当地社区常住人口中NAFLD/NASH相关的肝因性死亡病例,率的比较应用χ2检验,计量资料应用t检验,P<0.05为差异有统计学意义。结果总死亡率为220.5/10万。其中肝病死亡专率为24.2/10万,有15例死于NAFLD非酒精性脂肪性肝炎(nonalcohlic steatohepatitis,NASH)相关的肝硬化,死亡专率为2.8/10万,占肝硬化死亡者的32.6%,占所有死亡人数的1.25%,男女性NAFLD死亡率差异无显著性,未发现NAFLD相关肝癌死亡的病例。NAFLD肝因性死亡的平均年龄为63.9岁,患者比一般人群早3.59年。结论佛山市澜石社区NAFLD的患病率和死亡率尚处于较低水平,由于NAFLD的肝因性死亡可使患者的平均寿命缩短,因此,积极治疗NAFLD相关性肝病将有利于延长患者的生命。

On the death due to non-alcoholic fatty liver disease in Lanshi community of Foshan City

Objective To investigate the death due to non-alcoholic fatty liver disease(NAFLD) in Lanshi community of Foshan city,so as to provide a basis for NAFLD prevention and control in community.Methods All death cases in community were retrospectively collected from national death reporting system between 2007 to 2011.With the inpatient medical records,the cases of NAFLD / NASH related deaths were screened among the residents in local communities.χ2 test was used for comparison of rates,t-test for measurement data,the result of P<0.05 was considered statistically significant.Results The total mortality rate was 220.5/105,and the specific death rate of liver disease was 24.2/105,in which 15 cases died of liver cirrhosis due to NAFLD/NASH,accounting for 32.6% of cirrhosis deaths and 1.25% of all deaths.There was no significant difference in mortality rate of NAFLD between males and females and no death cases of NAFLD related liver cancer were found.Cases of NAFLD usually died at an average age of 63.9,which was 3.59 years earlier than that of general groups.Conclusions The prevalence and mortality of NAFLD are still in a low level in Lanshi community.Treating NAFLD actively will prolong lives of patients for that NAFLD may cause deaths and shorten their lifespan.