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| 高压氧对卡那霉素致聋肾虚豚鼠耳蜗琥珀酸脱氢酶的影响 | |
| 引用本文： | 章菊琴,王永华,王枫,罗嵩. 高压氧对卡那霉素致聋肾虚豚鼠耳蜗琥珀酸脱氢酶的影响[J]. 浙江中医药大学学报, 2010, 34(4) |
| 作者姓名： | 章菊琴 王永华 王枫 罗嵩 |
| 作者单位： | 1. 浙江省宁波市医疗中心李惠利医院,宁波,315010 2. 浙江中医药大学听力与言语科学学院 3. 余杭第三人民医院 |
| 摘 要： | [目的]观察高压氧(HBO)对卡那霉素致聋肾虚豚鼠的耳蜗琥珀酸脱氢霉(SDH)变化的影响。[方法]将30只雄性豚鼠随机分为3组,每组10只,分别为正常对照组(正常组)、肾虚耳聋模型对照组(模型组)、肾虚耳聋高压氧治疗组(治疗组),以听性脑干反应(ABR)及SDH组织化学检测为指标。[结果]模型组豚鼠ABR反应阈明显升高,治疗组ABR反应阈升高幅度明显低于模型组,两组比较差异有统计学意义(P0.05);模型组SDH显色变淡或消失,毛细胞受损显著,治疗组SDH变化、毛细胞受损程度均明显低于模型组。[结论]HBO能提高内耳SDH的活性,促进受损细胞功能恢复,对卡那霉素致聋肾虚型豚鼠有一定的治疗作用。 |
| 关 键 词： | 高压氧 琥珀酸脱氢霉 肾虚 耳聋 |
The Effect of Hyperbaric Oxygen on Succinate Dehydrogenase of Kanamycin Induced Ototoxic Cochlear in Kidney-deficiency Guinea Pig |
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| Zhang Juqin,Wang Yonghua,Wang Feng,et al Lihuili Hospital of Medical Center of Ningbo City,Zhejiang Province. The Effect of Hyperbaric Oxygen on Succinate Dehydrogenase of Kanamycin Induced Ototoxic Cochlear in Kidney-deficiency Guinea Pig[J]. Journal of Zhejiang University of Traditional Chinese Medicine, 2010, 34(4) | |
| Authors: | Zhang Juqin Wang Yonghua Wang Feng et al Lihuili Hospital of Medical Center of Ningbo City Zhejiang Province |
| Affiliation: | Zhang Juqin1,Wang Yonghua2,Wang Feng2,et al Lihuili Hospital of Medical Center of Ningbo City,Zhejiang Province(315010) |
| Abstract: | [Objective] To observe the effect of hyperbaric oxygen(HBO)on succinate dehydrogenase (SDH)of kanamycin induced ototoxic cochlear hair cells in kidney-deficiency guinea pig.[Methods]30 healthy male guinea pigs were divided randomly into three groups:normal group,model group and therapy group,10 in each group.Auditory brain stem response (ABR)and SDH in the cochlear hair cells were taken as indexes.[Results]The thresholds of ABR of the guinea pigs in the model group rose markedly,while those of therapy group... |
| Keywords: | hyperbaric oxygen succinate dehydrogenase kidney-deficiency deafness |
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