Gamma/deltaT-cell subsets, NKG2A expression and apoptosis of Vdelta2+ T cells in pregnant women with or without risk of premature pregnancy termination |
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Authors: | Szereday Laszlo Barakonyi Aliz Miko Eva Varga Peter Szekeres-Bartho Julia |
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Affiliation: | Department of Medical Microbiology and Immunology, Pecs University Medical School, Pecs, Hungary. |
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Abstract: | PROBLEM: Potentially cytotoxic Vdelta2+ T lymphocytes recognize human leukocyte antigen-E on the trophoblast via their CD94/NKG2A receptors. This study aims at determing the percentage of gamma/delta T-cell subsets, their NKG2A and Annexin V positivity in peripheral blood of healthy pregnant women and women at risk of premature pregnancy termination. METHOD OF STUDY: Peripheral Vdelta2+ cells from healthy pregnant women and from women at risk of premature pregnancy termination were tested for the KIR NKG2A and Annexin V positivity by flow cytometry. RESULTS: The percentage of viable Vdelta2+ T cells was higher, that of Vdelta1+ T cells was lower in women at risk of premature pregnancy termination than in healthy pregnant women. The percentage of NKG2A + Vdelta2+ T cells was significantly lower in pregnant women at risk of premature pregnancy termination than in normal pregnancy. CONCLUSIONS: These data suggest the involvement of gamma/delta T lymphocytes in the pathogenesis of premature pregnancy termination. |
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Keywords: | apoptosis CD94/NKG2A pregnancy γ /δ T cells |
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