环氧化酶-2在子宫内膜样腺癌中的表达及其与PTEN的相关性

 目的 研究环氧化酶-2（COX-2）在子宫内膜样腺癌（EAC）中的表达及意义，探讨COX-2与PTEN的相关性。方法 用免疫组化SP法检测COX-2、PTEN在正常子宫内膜、子宫内膜非典型增生及EAC中的表达。结果 COX-2的阳性表达率自正常内膜至非典型增生及EAC呈阶梯性升高（13.33 %、50.00 %、64.58 %）（P＜0.05）。EAC中，COX-2蛋白表达与组织分级（G1、G2、G3分别为4／9、64.29 %、81.82 %）、肌层浸润（深肌层浸润、浅肌层浸润分别为75.00 %、57.14 %）、手术-病理分期（早期、晚期分别为56.41 %、9／9）、淋巴转移（有、无分别为9／9 、56.41 %）相关（P = 0.007，P = 0.009，P = 0.001，P = 0.001）。预后好的EAC中，COX-2与 PTEN之间存在负相关（rs = -0.400，P＜0.05）。结论 COX-2与EAC的浸润转移相关；预后好的EAC中，PTEN可能参与COX-2的表达调控。

Expression of COX-2 and the relationship between COX-2 and PTEN in endometrial adenocarcinoma

Objective To study the expression and clinical significance of COX-2 and the relation－ship between COX-2 and PTEN in endometrial adenocarcinoma(EAC). Methods The expression of COX-2,PTEN protein was detected by SP-immunohistochemical method in EAC, endometrial intraepithelial neoplasia, corresponding normal endometrium. Results The positive rates of COX-2 protein increased from normal en－dometrium（13.33 %） to endometrial intraepithelial neoplasia(50.00 %) and adenocarcinoma(64.58 %)（P<0.05）. COX-2 positive ratio was higher in poorer differentiation(81.82 % vs 64.29 % vs 4/9, P = 0.007),deeper myometrial invasion(75.00 % vs 57.14 %, P = 0.009), extrauterine invasion/ metastasis and later stage(9/9 vs 56.41 %, P = 0.001)(P <0.05). In EAC with favorable prognosis, the expression pattern of COX-2 was correlated with PTEN（rs = -0.400, P <0.05）. Conclusion COX-2 may be a parameter indicating tumor ag－gressiveness. In EAC with favorable prognosis, PTEN may regulate the expression of COX-2 protein.