慢性前列腺炎与IgA肾病关系初探

目的 探讨慢性前列腺炎（CP）在IgA肾病（IgAN）发生、发展中的作用。方法 选择系膜增生性肾小球肾炎患者89例，其中IgAN组38例，非IgAN系膜增生性肾小球肾炎组51例，比较其CP的发生率。另选择IgAN男性患者51例，分为无CP组24例和CP组27例，比较二者的临床和病理指标。观察伴CP的IgAN患者抗炎治疗后的疗效。结果 38例IgAN患者的CP发生率为44．7％，51例非IgAN患者的CP发生率为21．6％，两者间比较差异显著（P〈0．05）。伴CP组肾小球硬化发生率和血管襻免疫复合物沉积率较不伴CP组高（P〈0．05），其他病理指标及临床指标两组间无差异。抗CP治疗可使部分IgAN患者病情获得好转。结论 CP可能参与了IgAN的发生和发展过程。

An preliminary study of the relationship between chronic prostatitis and IgA nephropathy

Objective To study the role of chronic prostatitis(CP)in the pathogenesis and development of IgA nephropathy(IgAN). Methods The incidence rate of CP was compared between the patients with IgAN and the patients with non-IgA mesangial proliferative glomerulonephritis. Furthermore, the clinical and pathological features were compared between the IgAN patients without CP and those with CP. The therapeutic effect of anti-inflammatory treatment in IgAN patients with CP was evaluated. Results Incidence of CP in IgAN patients was 44.7% and that in non-IgA mesangial proliferative glomerulonephritis patients was 21.6%. There was significant difference in the incidence of chronic prostatitis between the two groups. The incidence of glomerular sclerosis and the deposition of immune complexes in vascular wall in IgAN patients with CP were higher than that in patients without CP. The treatment of CP may be beneficial in ameliorating IgAN in some patients. Conclusion Chronic prostatitis is one of the probable pathogenetic factors in IgAN.